Drug-induced haemolysis, renal failure, thrombocytopenia and lactic acidosis in patients with HIV and cryptococcal meningitis: a diagnostic challenge

Int J STD AIDS. 2015 Dec;26(14):1052-4. doi: 10.1177/0956462414567547. Epub 2015 Jan 22.

Abstract

Patients with HIV are at risk of both primary and secondary haematological disorders. We report two cases of patients with HIV and cryptococcal meningitis who developed severe haemolytic anaemia, thrombocytopenia, renal failure and lactic acidosis while on treatment with amphotericin B and co-trimoxazole.

Keywords: AIDS; Cryptococcal meningitis; HIV; Haemolysis; cryptococcosis; lactic acidosis; renal failure; thrombocytopenia.

Publication types

  • Case Reports

MeSH terms

  • AIDS-Related Opportunistic Infections / drug therapy
  • AIDS-Related Opportunistic Infections / microbiology
  • Acidosis, Lactic / chemically induced*
  • Acidosis, Lactic / diagnosis
  • Adult
  • Amphotericin B / administration & dosage
  • Amphotericin B / adverse effects*
  • Amphotericin B / therapeutic use
  • Anemia, Hemolytic / chemically induced*
  • Anemia, Hemolytic / diagnosis
  • Antifungal Agents / adverse effects
  • Antifungal Agents / therapeutic use*
  • Cryptococcus neoformans / drug effects*
  • Cryptococcus neoformans / isolation & purification
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Meningitis, Cryptococcal / diagnosis
  • Meningitis, Cryptococcal / drug therapy*
  • Renal Insufficiency / chemically induced*
  • Renal Insufficiency / diagnosis
  • Thrombocytopenia / chemically induced*
  • Thrombocytopenia / diagnosis
  • Treatment Outcome
  • Trimethoprim, Sulfamethoxazole Drug Combination / administration & dosage
  • Trimethoprim, Sulfamethoxazole Drug Combination / adverse effects*
  • Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use

Substances

  • Antifungal Agents
  • Amphotericin B
  • Trimethoprim, Sulfamethoxazole Drug Combination