Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish

J R Kelsoe; E I Ginns; J A Egeland; D S Gerhard; A M Goldstein; S J Bale; D L Pauls; R T Long; K K Kidd; G Conte

doi:10.1038/342238a0

Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish

Nature. 1989 Nov 16;342(6247):238-43. doi: 10.1038/342238a0.

Authors

J R Kelsoe¹, E I Ginns, J A Egeland, D S Gerhard, A M Goldstein, S J Bale, D L Pauls, R T Long, K K Kidd, G Conte, et al.

Affiliation

¹ Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, Maryland 20892.

PMID: 2682265
DOI: 10.1038/342238a0

Abstract

Reanalysis of an Old Order Amish pedigree, to include several new individuals and two changes in clinical status, markedly reduces the probability of linkage between bipolar affective disorder and the Harvey-ras-1 oncogene and insulin loci on chromosome 11. This linkage can be excluded using a large lateral extension of the original Amish pedigree.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Bipolar Disorder / diagnosis
Bipolar Disorder / genetics*
Chromosomes, Human, Pair 11*
Ethnicity
Genes, ras
Genetic Linkage
Genotype
Humans
Insulin / genetics
Pedigree
Pennsylvania

Substances

Insulin