Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

Intensive Care Med. 2020 Apr;46(4):586-590. doi: 10.1007/s00134-020-05985-9. Epub 2020 Mar 3.

Haibo Zhang^{1

2

3}, Josef M Penninger^{4

5}, Yimin Li², Nanshan Zhong², Arthur S Slutsky^{6

7

8}

¹ The Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michaels Hospital, 209 Victoria Street, Room 608, Toronto, ON, M5B 1T8, Canada.
² The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
³ Interdepartmental Division of Critical Care Medicine; Departments of Anesthesia and Physiology, University of Toronto, Toronto, Canada.
⁴ Department of Medical Genetics, Life Science Institute, University of British Columbia, Vancouver, BC, Canada.
⁵ IMBA, Institute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna, Austria.
⁶ The Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michaels Hospital, 209 Victoria Street, Room 608, Toronto, ON, M5B 1T8, Canada. arthur.slutsky@unityhealth.to.
⁷ Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada. arthur.slutsky@unityhealth.to.
⁸ The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. arthur.slutsky@unityhealth.to.

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