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19952298,19801361,21293084,17263764,22104467,18786605,16503716,17655515,16682937,19217790,18525067,15495988,18299314,22989472,19022515,17383951,16517403,17724014,21441754,19182763,18269436,21194578,18600568,21871831,20115929,19748065,17983555,20737753,20644202,16050953,11460578,22471248,20206729,18600596,17486662,21958333,20824239,17407649,16625820,17109672,23231438,24647737,21281062,21484567,23748503,21517657,21864749,22405266,21665041,22015634,21094909,18020966,20382839,19766644,22738299,23433601,26768240,21664294,20465123,23548652,21813733,21673098,19421931,22545749,17160910,19900193,21332446,23707531,24186866,20824238,24889731,19947814,23077965,24989141,20591345,17353295,19275672,22186413,24296715,21752172,19748062,18820816,15111503,20446595,23216746,24918792,26489970,21665040,23415157,22420869,19330494,22626875,20196038,22425330,18512528,22913894,20584260,21205117,21574000,17877544,20500049,23926280,17315049,19580949,19464426,18174966,23859800,24131508,29364588,17928394,34819089,18801896,22672960,22411425,18435775,16202636,22340428,16488579,24269216,19947817,28847797,15780432,19748061,24140094,20708812,18628530,24320037,27125902,22323472,20198559,27056542,24962916,25065315,20954337,17940451,23459193,34310013,27933595,19074620,21106865,18205109,25704082,18806525,14514604,22284241,26104180,28869249,18202141,17717280,20804731,18313669,20029928,32308645,17958029,25010023,20336594,24500557,25437459,27282159,20609666,22555471,21738030,19218562,20844284,17407650,15655721,24696447,18054732,20196037,32390941,16416146,22172989,25852133,28873383,21460410,21205499,35796651,31414143,19878258,17498508,32325333,20380648,16142014,22439700,25326837,22868389,23057494,20444564,21534885,23643015,10550416,21824261,25284699,18777503,31982487,19179813,27502601,24148218,22165692,18427132,33247879,28351157,19881250,22267300,22429011,22093196,23617798,22820565,30028989,22167829,27276528,21824266,19748060,20409967,32459834,23471186,22017411,15765627,19464427,21595278,22832924,21747318,30372907,17981665,26774018,21595259,12641488,25326836,20092903,32098413,19275548,24855202,25007170,20448207,23523778,26876794,21048706,19170358,29950546,31706956,22947920,19748063,20736387,22112254,31276666,22963445,21802579,20039889,16318402,20519806,22390806,24373234,17981667,21951387,20571352,25415611,19879210,16898571,18220652,23967137,16800760,17662202,21194543,23523140,23818527,19464424,20655673,25582643,22995389,25803196,22564773,18533126,21094905,21086586,21595286,21094906,29264724,18795210,22262068,25623632,18217245,20546289,20305008,22410395,17988596,22721966,25456646,25311717,31425698,22932289,21299778,19442094,20518750,19586609,29412815,25323297,17553392,23674605,30417596,24604239,34861327,21595258,25903418,22475049,19679451,24565847,28544214,31199957,26796275,17090794,17352676,24352410,35050311,21564347,22587735,16241889,20871975,23214078,34984794,24583767,25656369,25326838,15561911,26997369,21474688,25060530,25913633,27186361,23083681,25694217,26549734,20425582,33964357,21595269,27304951,27483245,29325553,25219868,32543789,24929856,21966329,31225553,28007055,30248550,19820277,27839908,17491680,28413961,29540315,22705459,36043753,24747994,22648661,31643819,21595279,18201204,20217513,22577369,24666399,24676508,20831513,36077491,36989115,33339298,21595261,20196036,25648286,29091882,34081167,24352344,25071023,31688969,27771154,28420649,31392745,21361052,21336840,19146796,21595282,15331525,33116039,26107658,23375875,34710367,29692250,28526921,35767712,32481541,34535873,36077515,26111634,16004598,33503878,21414305,30743780,27562982,21782840,35487405,29409356,22085632,35593668,23125920,22933106,21812895,22555472,21094910,25355151,20519242,36516422,20594158,25100362,27238050,35031999,11832466,22566312,24843641,34956089,21612069,34048925,20532013,26813306,23645229,22871675,18855626,21595283,24092928,15860408,23523479,26541763,30428906,20638440,27692167,35399928,33897622,22262070,32656265,20621378,32810485,29412811,27110066,31189118,33671882,36209967,20197503,23697580,31050435,26739488,27142144,25883113,18930564,29905825,27180961,25004768,24931645,26447772,26072069,36498958,28433470,19073224,26515908,20368408,21525466,23107049,33935978,34126341,29603541,31643415,36093924,24684709,31412576,27091492,36440220,16629719,30186862,23684623,20714888,29728598,20467925,34205264,23925432,34830194,30736202,21595271,24018562,21437082,33952814,26001654,35753504,23918649,30780831,30991794,35830001,26075286,24996388,25360712,24854977,22272906,36289848,20575217,31080438,26666142,29632608,22701844,20727514,24245943,8001623,25011640,17272793,25980358,19336511,26205746,34350681,29308856,20043037,28344207,24444412,25614665,30058933,21210936,26786687,36014373,27031273,21256171,22111033,29659121,21517656,24831459,18753109,22127804,24372241,25325735,29522713,17951498,29412810,30736119,34207217,25364668,28040864,16700515,34521773,25264749,36677809,24684301,31124035,25231355,23764734,22691625,26146634,35745639,31640215,25309791,30104246,24910203,22761607,23524641,223903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Role of the incretin pathway in the pathogenesis of type 2 diabetes mellitus.

Freeman JS. Freeman JS. Cleve Clin J Med. 2009 Dec;76 Suppl 5:S12-9. doi: 10.3949/ccjm.76.s5.03. Cleve Clin J Med. 2009. PMID: 19952298 Free article. Review.

Differential chemistry (structure), mechanism of action, and pharmacology of GLP-1 receptor agonists and DPP-4 inhibitors.

Neumiller JJ. Neumiller JJ. J Am Pharm Assoc (2003). 2009 Sep-Oct;49 Suppl 1:S16-29. doi: 10.1331/JAPhA.2009.09078. J Am Pharm Assoc (2003). 2009. PMID: 19801361 Review.

Focus on incretin-based therapies: targeting the core defects of type 2 diabetes.

Jellinger PS. Jellinger PS. Postgrad Med. 2011 Jan;123(1):53-65. doi: 10.3810/pgm.2011.01.2245. Postgrad Med. 2011. PMID: 21293084 Review.

Incretins and other peptides in the treatment of diabetes.

Todd JF, Bloom SR. Todd JF, et al. Diabet Med. 2007 Mar;24(3):223-32. doi: 10.1111/j.1464-5491.2006.02071.x. Diabet Med. 2007. PMID: 17263764 Review.

The pharmacologic basis for clinical differences among GLP-1 receptor agonists and DPP-4 inhibitors.

Morales J. Morales J. Postgrad Med. 2011 Nov;123(6):189-201. doi: 10.3810/pgm.2011.11.2508. Postgrad Med. 2011. PMID: 22104467

The incretin system and its role in type 2 diabetes mellitus.

Holst JJ, Vilsbøll T, Deacon CF. Holst JJ, et al. Mol Cell Endocrinol. 2009 Jan 15;297(1-2):127-36. doi: 10.1016/j.mce.2008.08.012. Epub 2008 Aug 20. Mol Cell Endocrinol. 2009. PMID: 18786605 Review.

Incretin mimetics and dipeptidyl peptidase-IV inhibitors: potential new therapies for type 2 diabetes mellitus.

Triplitt C, Wright A, Chiquette E. Triplitt C, et al. Pharmacotherapy. 2006 Mar;26(3):360-74. doi: 10.1592/phco.26.3.360. Pharmacotherapy. 2006. PMID: 16503716 Review.

Dipeptidyl peptidase IV inhibitors and the incretin system in type 2 diabetes mellitus.

Langley AK, Suffoletta TJ, Jennings HR. Langley AK, et al. Pharmacotherapy. 2007 Aug;27(8):1163-80. doi: 10.1592/phco.27.8.1163. Pharmacotherapy. 2007. PMID: 17655515 Review.

Therapies for the treatment of type 2 diabetes mellitus based on incretin action.

Gallwitz B. Gallwitz B. Minerva Endocrinol. 2006 Jun;31(2):133-47. Minerva Endocrinol. 2006. PMID: 16682937 Review.

Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes.

Havale SH, Pal M. Havale SH, et al. Bioorg Med Chem. 2009 Mar 1;17(5):1783-802. doi: 10.1016/j.bmc.2009.01.061. Epub 2009 Jan 31. Bioorg Med Chem. 2009. PMID: 19217790 Review.

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