[HTML][HTML] Lipoprotein-X reduces LDL atherogenicity in primary biliary cirrhosis by preventing LDL oxidation
PY Chang, SC Lu, TC Su, SF Chou, WH Huang… - Journal of lipid …, 2004 - ASBMB
Hypercholesterolemic human LDL contains oxidized subfractions that have atherogenic
properties. Paradoxically, atherosclerosis incidence is low in patients with primary biliary
cirrhosis (PBC), a disease characterized by marked increases in plasma LDL, including the
LDL subfraction lipoprotein-X (Lp-X). To investigate the mechanisms underlying this
paradox, we first examined the propensity to oxidation of unfractionated LDL isolated from
PBC patients. After prolonged incubation with copper, PBC-LDL failed to increase the …
properties. Paradoxically, atherosclerosis incidence is low in patients with primary biliary
cirrhosis (PBC), a disease characterized by marked increases in plasma LDL, including the
LDL subfraction lipoprotein-X (Lp-X). To investigate the mechanisms underlying this
paradox, we first examined the propensity to oxidation of unfractionated LDL isolated from
PBC patients. After prolonged incubation with copper, PBC-LDL failed to increase the …