ContextPregnancy has historically been described as a time of emotional well-being,
providing “protection” against psychiatric disorder. However, systematic delineation of risk of …

Objective: This study estimated the risk of recurrence of mood episodes among women with
a history of bipolar disorder who continued or discontinued treatment with mood stabilizers …

OBJECTIVE: Pregnancy poses major challenges for the treatment of bipolar disorder, and
information to guide clinical care remains very sparse. The authors sought to determine the …

Objective: The risks of major affective episodes during pregnancy and during the postpartum
period have rarely been compared in large samples across diagnoses. The authors …

Background: Abrupt discontinuation of long-term psychotropic medication can be followed
by a high risk of early relapse. This study aimed to quantify the relapse risk over time in …

Objectives: There are limited data regarding the use of atypical antipsychotic medications in
pregnancy. The objectives of the current study were to quantify placental permeability to …

OBJECTIVE: Lithium has been used during pregnancy for more than four decades, but
quantification of fetal lithium exposure and clinical correlations of such exposure are limited. The …

Objective: Current practice guidelines discourage use of lithium during breast-feeding, despite
limited data. This study aimed to quantify lithium exposure in nursing infants. Method: In …

Objective: To review research findings on clinical effects of discontinuing lithium maintenance
treatment. Methods: Data from studies reported since 1970 plus our recent findings were …

Background: Challenges for the clinical management of bipolar disorder (BD) during pregnancy
are multiple and complex and include competing risks to mother and offspring. Method: …