Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis

…, KM O'Neil, AS Zeft, IS Szer, S Ringold… - Arthritis & …, 2012 - Wiley Online Library
Objective To determine whether aggressive treatment initiated early in the course of rheumatoid
factor (RF)–positive or RF‐negative polyarticular juvenile idiopathic arthritis (JIA) can …

Classification, presentation, and initial treatment of Wegener's granulomatosis in childhood

…, PJ Hashkes, G Higgins, AS Zeft… - … : Official Journal of …, 2009 - Wiley Online Library
Objective To compare the criteria for Wegener's granulomatosis (WG) of the American
College of Rheumatology (ACR) with those of the European League Against Rheumatism/…

HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis

…, S Özen, S Prahalad, AS Zeft… - Proceedings of the …, 2015 - National Acad Sciences
Systemic juvenile idiopathic arthritis (sJIA) is an often severe, potentially life-threatening
childhood inflammatory disease, the pathophysiology of which is poorly understood. To …

Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications

…, M Gattorno, S Özen, S Prahalad, AS Zeft… - Annals of the …, 2017 - ard.bmj.com
Objectives Juvenile idiopathic arthritis (JIA) is a heterogeneous group of conditions unified
by the presence of chronic childhood arthritis without an identifiable cause. Systemic JIA (sJIA…

Clinically inactive disease in a cohort of children with new-onset polyarticular juvenile idiopathic arthritis treated with early aggressive therapy: time to achievement …

…, KM O'Neil, AS Zeft, IS Szer, S Ringold… - The Journal of …, 2014 - jrheum.org
Objective. To determine the elapsed time while receiving aggressive therapy to the first
observation of clinically inactive disease (CID), total duration of CID and potential predictors of …

Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis

S Prahalad, S Hansen, A Whiting… - … : Official Journal of …, 2009 - Wiley Online Library
Objective Subtypes of juvenile idiopathic arthritis (JIA) share phenotypic features with other
autoimmune disorders. We investigated several genetic variants associated with rheumatoid …

Quantification of the familial contribution to juvenile idiopathic arthritis

S Prahalad, AS Zeft, R Pimentel, B Clifford… - Arthritis & …, 2010 - Wiley Online Library
Objective We previously demonstrated that there is familial aggregation of juvenile idiopathic
arthritis (JIA). Using a large JIA cohort, we sought to identify additional clusters of JIA cases …

[HTML][HTML] Takayasu arteritis in the pediatric population: a contemporary United States-based single center cohort

HS Szugye, AS Zeft, SJ Spalding - Pediatric Rheumatology, 2014 - Springer
Background Takayasu Arteritis is an idiopathic, chronic, large vessel vasculitis involving the
aorta and its primary branches. Few studies have been done in pediatric patients to date …

IL1RN Variation Influences Both Disease Susceptibility and Response to Recombinant Human Interleukin‐1 Receptor Antagonist Therapy in Systemic Juvenile …

…, M Gattorno, S Özen, S Prahalad, AS Zeft… - Arthritis & …, 2018 - Wiley Online Library
Objective To determine whether systemic juvenile idiopathic arthritis (JIA) susceptibility loci
that were identified by candidate gene studies demonstrate association with systemic JIA in …

Hierarchy of risk of childhood‐onset rheumatoid arthritis conferred by HLA–DRB1 alleles encoding the shared epitope

…, A Reed, JL Park, ED Mellins, AS Zeft… - Arthritis & …, 2012 - Wiley Online Library
Objective Associations between shared epitope (SE)–encoding HLA–DRB1 alleles and
rheumatoid arthritis (RA) are well established. However, only a limited number of studies have …