Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors
Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC)
class I antigens, preventing attack against healthy cells. Mouse cytomegalovirus (MCMV) …
class I antigens, preventing attack against healthy cells. Mouse cytomegalovirus (MCMV) …
Four distinct patterns of memory CD8 T cell responses to chronic murine cytomegalovirus infection
…, AK Pinto, S Sierro, P Klenerman, AB Hill - The Journal of …, 2006 - journals.aai.org
CMVs are β herpesviruses that establish lifelong latent infection of their hosts. Acute infection
of C57BL/6 mice with murine CMV elicits a very broad CD8 T cell response, comprising at …
of C57BL/6 mice with murine CMV elicits a very broad CD8 T cell response, comprising at …
[HTML][HTML] Sustained CD8+ T cell memory inflation after infection with a single-cycle cytomegalovirus
…, KS Cho, EL Bonnett, JE Allan, AB Hill - PLoS …, 2011 - journals.plos.org
Cytomegalovirus (CMV) is a β-herpesvirus that establishes a lifelong latent or persistent
infection. A hallmark of chronic CMV infection is the lifelong persistence of large numbers of virus…
infection. A hallmark of chronic CMV infection is the lifelong persistence of large numbers of virus…
Herpes simplex virus turns off the TAP to evade host immunity
A Hill, P Jugovic, lan York, G Russ, J Bennink… - Nature, 1995 - nature.com
MANY viruses have evolved mechanisms to avoid detection by the host immune system.
Herpes simplex virus (HSV) expresses an immediate early protein, ICP47, which blocks …
Herpes simplex virus (HSV) expresses an immediate early protein, ICP47, which blocks …
T cells and viral persistence: lessons from diverse infections
P Klenerman, A Hill - Nature immunology, 2005 - nature.com
Persistent virus infections create specific problems for their hosts. Although the dynamics of
immune responses after acute infection are well studied and very consistent, especially in …
immune responses after acute infection are well studied and very consistent, especially in …
[PDF][PDF] Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T cells
…, EL Bonnett, S van Dommelen, GR Shellam, AB Hill - Immunity, 2008 - cell.com
During persistent murine cytomegalovirus (MCMV) infection, the T cell response is maintained
at extremely high intensity for the life of the host. These cells closely resemble human …
at extremely high intensity for the life of the host. These cells closely resemble human …
[PDF][PDF] Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin
…, R Adhikari, M Howarth, K Nakamura, MC Gold, AB Hill… - Immunity, 2002 - cell.com
MHC class I molecules expressed in a calreticulin-deficient cell line (K42) assembled with β
2-microglobulin (β2-m) normally, but their subsequent loading with optimal peptides was …
2-microglobulin (β2-m) normally, but their subsequent loading with optimal peptides was …
Problem solving in real-life contexts: An alternative for design in technology education
AM Hill - International journal of technology and design …, 1998 - Springer
This article focuses on one way to study technology, through technological problem solving
situated in real-life contexts. In problem solving for real-life contexts, design processes are …
situated in real-life contexts. In problem solving for real-life contexts, design processes are …
[HTML][HTML] Viral interference with antigen presentation
JW Yewdell, AB Hill - Nature immunology, 2002 - nature.com
CD8 + T cells play an important role in immunity to viruses. Just how important these cells are
is demonstrated by the evolution of viral strategies for blocking the generation or display of …
is demonstrated by the evolution of viral strategies for blocking the generation or display of …
Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP.
R Tomazin, AB Hill, P Jugovic, I York… - The EMBO …, 1996 - embopress.org
The herpes simplex virus (HSV) ICP47 protein inhibits the MHC class I antigen presentation
pathway by inhibiting the transporter associated with antigen presentation (TAP) which …
pathway by inhibiting the transporter associated with antigen presentation (TAP) which …