Protective role of endothelial nitric oxide synthase

EWJA Albrecht, CA Stegeman… - The Journal of …, 2003 - Wiley Online Library
… level of free Ca 2+ causes the formation of Ca 2+ /CaM … remains so until intracellular Ca
2+ levels drop and the Ca 2+ /… Ca 2+ , caused by either influx of extracellular Ca 2+ or Ca 2+ …

Mechanisms of disease: pathogenesis and treatment of ANCA-associated vasculitides

…, P Heeringa, CA Stegeman - Nature Clinical Practice …, 2006 - nature.com
Wegener's granulomatosis and microscopic polyangiitis are idiopathic systemic vasculitides
strongly associated with antineutrophil cytoplasmic autoantibodies (ANCA). In Wegener's …

[HTML][HTML] Antiproteinase 3-and antimyeloperoxidase-associated vasculitis

CFM Franssen, CA Stegeman, CGM Kallenberg… - Kidney international, 2000 - Elsevier
Stegeman et al have shown that relapses occur almost exclusively in those patients with
Wegener's granulomatosis who are persistently or intermittently C-ANCA positive 100 . Thus, …

Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis

…, COS Savage, RA Sinico, CA Stegeman… - Journal of the …, 2007 - journals.lww.com
Systemic vasculitis associated with autoantibodies to neutrophil cytoplasmic antigens (ANCA)
is the most frequent cause of rapidly progressive glomerulonephritis. Renal failure at …

[HTML][HTML] Genetically distinct subsets within ANCA-associated vasculitis

…, M Segelmark, CA Stegeman… - … England Journal of …, 2012 - Mass Medical Soc
Background Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a severe
condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly …

[HTML][HTML] Trimethoprim–sulfamethoxazole (co-trimoxazole) for the prevention of relapses of Wegener's granulomatosis

CA Stegeman, JW Cohen Tervaert… - … England Journal of …, 1996 - Mass Medical Soc
Background Respiratory tract infections may trigger relapses in patients with Wegener's
granu-lomatosis in remission. Uncontrolled data have suggested that treatment with trimethoprim…

Association of Chronic Nasal Carriage of Staphylococcus aureus and Higher Relapse Rates in Wegener Granulomatosis

CA Stegeman, JWC Tervaert, WJ Sluiter… - Annals of internal …, 1994 - acpjournals.org
Objective: To examine possible risk factors for relapse, including chronic nasal carriage of
Staphylococcus aureus and serial antineutrophil cytoplasmic antibody (ANCA) determinations …

Tubular kidney injury molecule‐1 (KIM‐1) in human renal disease

…, SJL Bakker, H van Goor, CA Stegeman - The Journal of …, 2007 - Wiley Online Library
KIM‐1, a transmembrane tubular protein with unknown function, is undetectable in normal
kidneys, but is markedly induced in experimental renal injury. The KIM‐1 ectodomain is …

Immediate postoperative renal function deterioration in cardiac surgical patients predicts in-hospital mortality and long-term survival

…, T Ebels, G Navis, CA Stegeman - Journal of the …, 2005 - journals.lww.com
Postoperative renal function deterioration is a serious complication after cardiac surgery with
cardiopulmonary bypass and is associated with increased in-hospital mortality. However, …

Prediction of relapses in Wegener's granulomatosis by measurement of antineutrophil cytoplasmic antibody levels: a prospective study

MM Boomsma, CA Stegeman… - … : Official Journal of …, 2000 - Wiley Online Library
Objective Prediction of relapses in Wegener's granulomatosis (WG) by measuring levels of
antineutrophil cytoplasmic antibodies (ANCA) directed against proteinase 3 (PR3) or …