[HTML][HTML] Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02
Frontal fibrosing alopecia (FFA) is a recently described inflammatory and scarring type of hair
loss affecting almost exclusively women. Despite a dramatic recent increase in incidence …
loss affecting almost exclusively women. Despite a dramatic recent increase in incidence …
Lichen planus and lichenoid dermatoses: clinical overview and molecular basis
Deriving from the Greek word λειχήν for “tree moss” and the Latin word planus for “planar,”
lichen planus is a relatively uncommon and heterogeneous cutaneous disorder that typically …
lichen planus is a relatively uncommon and heterogeneous cutaneous disorder that typically …
Frontal fibrosing alopecia: reflections and hypotheses on aetiology and pathogenesis
C Tziotzios, CM Stefanato, DA Fenton… - Experimental …, 2016 - Wiley Online Library
Since first described by Kossard in 1994, frontal fibrosing alopecia ( FFA ) has been something
of an enigma. The clinical heterogeneity of FFA , its apparent rarity and investigators' …
of an enigma. The clinical heterogeneity of FFA , its apparent rarity and investigators' …
Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics: Part I. The molecular basis of scar formation
C Profyris, C Tziotzios, I Do Vale - Journal of the American Academy of …, 2012 - Elsevier
Cutaneous scarring is often the epicenter of patient-related concerns, and the question “Will
there be a scar?” is one that is all too familiar to the everyday clinician. In approaching this …
there be a scar?” is one that is all too familiar to the everyday clinician. In approaching this …
Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA
…, TN Darling, J Geer, Z Gucev, VR Sutton, C Tziotzios… - Nature …, 2012 - nature.com
The phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway is critical for cellular growth
and metabolism. Correspondingly, loss of function of PTEN, a negative regulator of PI3K, or …
and metabolism. Correspondingly, loss of function of PTEN, a negative regulator of PI3K, or …
Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics: Part II. Strategies to reduce scar formation after dermatologic …
C Tziotzios, C Profyris, J Sterling - Journal of the American Academy of …, 2012 - Elsevier
The evidence base underpinning most traditional scar reduction approaches is limited, but
some of the novel strategies are promising and accumulating. We review a number of …
some of the novel strategies are promising and accumulating. We review a number of …
[HTML][HTML] Safety and early efficacy outcomes for lentiviral fibroblast gene therapy in recessive dystrophic epidermolysis bullosa
…, M Martinez-Queipo, E Rashidghamat, C Tziotzios… - JCI insight, 2019 - ncbi.nlm.nih.gov
BACKGROUND Recessive dystrophic epidermolysis bullosa (RDEB) is a severe form of
skin fragility disorder due to mutations in COL7A1 encoding basement membrane type VII …
skin fragility disorder due to mutations in COL7A1 encoding basement membrane type VII …
The associated burden of mental health conditions in alopecia areata: a population‐based study in UK primary care
…, M Harries, WS Chiu, C Tziotzios… - British Journal of …, 2022 - academic.oup.com
Background Alopecia areata (AA) is a common cause of nonscarring hair loss that can have
a profound psychological impact. Objectives To assess the co‐occurrence of depression …
a profound psychological impact. Objectives To assess the co‐occurrence of depression …
Time series integrative analysis of RNA sequencing and microRNA expression data reveals key biologic wound healing pathways in keloid-prone individuals
…, HY Huang, U Niazi, C Tziotzios… - The Journal of …, 2018 - pubmed.ncbi.nlm.nih.gov
… 5 , Christos Tziotzios …
Lichen planus and lichenoid dermatoses: Conventional and emerging therapeutic strategies
Having reviewed the diverse clinical subtypes of lichenoid disease and the postulated
molecular basis thereof in the first article in this 2-part continuing medical education series, we …
molecular basis thereof in the first article in this 2-part continuing medical education series, we …