Although intermittent increases in inflammation are critical for survival during physical injury
and infection, recent research has revealed that certain social, environmental and lifestyle …

Aprominent pathology textbook used in the United States includes an image illustrating the
renal histopathology caused by malignant hypertension. The legend describes striking “…

The ability to mount protective immune responses depends on the diversity of T cells. T cell
diversity may be compromised by the declining thymic output of new T cells. The aging …

Giant-cell arteritis typically involves extracranial branches of the aorta, such as the temporal
and vertebral arteries. Temporal arteritis and polymyalgia rheumatica often coexist, and …

In rheumatoid arthritis (RA), tissue-infiltrating lymphocytes can be arranged in sophisticated
organizations that resemble microstructures usually formed in secondary lymphoid organs. …

In the older adult, the benefits of vaccination to prevent infectious disease are limited, mainly
because of the adaptive immune system's inability to generate protective immunity. The age-…

Background—Unstable angina (UA) is associated with systemic inflammation and with
expansion of interferon-γ–producing T lymphocytes. The cause of T-cell activation and the …

Background: Tumor necrosis factor-α is present in arteries in giant cell arteritis. Objective: To
evaluate the efficacy of infliximab, an anti–tumor necrosis factor-α agent, in giant cell arteritis…

T-cell receptor (TCR) diversity, a prerequisite for immune system recognition of the universe
of foreign antigens, is generated in the first two decades of life in the thymus and then …

… Goronzy J , Oppitz U , and Weyand C . Clonal heterogeneity of superantigen reactivity in
human V beta 6+ T cell clones. Limited contributions of V beta sequence polymorphisms. …