Although the entire coronary tree is exposed to the atherogenic effect of the systemic risk
factors, atherosclerotic lesions form at specific arterial regions, where low and oscillatory …

Basic fibroblast growth factor has multivariate effects in stimulating cell growth and the
processes that surround tissue repair. Pathophysiologic studies have been hampered by the …

Background The first compounds considered for stent-based delivery, such as heparin, were
chosen on the basis of promising tissue culture and animal experiments, and yet they have …

Background— Stent thrombosis is a lethal complication of endovascular intervention. Concern
has been raised about the inherent risk associated with specific stent designs and drug-…

Successful implementation of local arterial drug delivery requires transmural distribution of
drug. The physicochemical properties of the applied compound, which govern its transport …

As the interventions available to treat obstructive coronary artery disease become increasingly
complex, our understanding of the vascular response to these interventions requires …

The in vivo mitogenicity of basic fibroblast growth factor (bFGF) for arterial smooth muscle
cells relies on the removal of endothelium, raising the question of whether the endothelium …

Diabetes mellitus (DM) has reached epidemic proportions worldwide, and its prevalence is
rising. 1, 2 The implications of a diagnosis of DM are as severe as a diagnosis of coronary …

Background Endothelial integrity is essential for maintaining vascular homeostasis, and
endothelial denudation results in neointimal thickening. Balloon-expandable endovascular …

The risk of atherosclerosis, a leading cause of cardiovascular disease and death, is
inversely related to plasma levels of high-density lipoprotein (HDL) cholesterol, although the …