Activation of phosphoinositide 3-kinase (PI3K)/Akt signaling is associated with growth and
progression of colorectal cancer (CRC). We have previously shown that the mTOR kinase, a …

Fatty acid synthase (FASN) and ATP-citrate lyase, key enzymes of de novo lipogenesis, are
significantly upregulated and activated in many cancers and portend poor prognosis. Even …

Green tea polyphenols (GrTP) have been previously shown to decrease endotoxin-induced
tumor necrosis factor-α production and lethality in mice. Our present studies demonstrate …

Purpose: The mammalian target of rapamycin (mTOR) kinase acts downstream of phosphoinositide
3-kinase/Akt to regulate cellular growth, metabolism, and cytoskeleton. Because ∼…

Fatty acid synthase (FASN), a lipogenic enzyme, is upregulated in colorectal cancer (CRC).
Increased de novo lipid synthesis is thought to be a metabolic adaptation of cancer cells that …

Blockade of programmed death-ligand 1 (PD-L1) by therapeutic antibodies has shown to be
a promising strategy in cancer therapy, yet clinical response in many types of cancer, …

… Madjid Karimi is a Health Scientist in the Office of Health Policy Euny C. Lee is a Health
Informatics Fellow in the Office of Health Policy Sara J. Coutureis a Health Informatics Fellow in …

Exposure to carcinogenic metals, such as trivalent arsenic [As(III)] and hexavalent chromium
[Cr(VI)], through drinking water is a major global public health problem and is associated …

The majority of deaths from all cancers, including colorectal cancer (CRC), is a result of tumor
metastasis to distant organs. To date, an effective and safe system capable of exclusively …

Fatty Acid Synthase (FASN), a key enzyme of de novo lipogenesis, is upregulated in many
cancers including colorectal cancer (CRC); increased FASN expression is associated with …