Human mast cells (hMCs) derived in vitro from cord blood mononuclear cells exhibit stem cell
factor (SCF)-dependent comitogenic responses to T helper cell type 2 (Th2) cytokines. As …

We hypothesized that analysis of single nucleotide polymorphism arrays (SNP-A) and new
molecular defects may provide new insight in the pathogenesis of systemic mastocytosis (SM)…

. ABSTRACT Blood tests are available that measure levels of immunoglobulin E (IgE) against
specific allergens such as foods, inhalants, medications, latex, and venoms. These tests …

Mast cells (MC) are stem cell factor-dependent tissue-based hematopoietic cells with
substantial functional heterogeneity. Cord blood-derived human MC (hMC) express functional …

… and Hsieh have indicated that this article does not include the discussion of unapproved/investigative
use of a commercial product/device. Financial disclosure: Drs Bains and Hsieh …

The idiopathic hypereosinophilic syndrome (HES) developed in a 15-year-old boy who
presented with colitis, cough, rash, and hepatitis. Molecular analysis failed to demonstrate the …

Objective To summarize the identified molecular and cellular mechanisms relevant to
clinicians evaluating patients with hypereosinophilic syndrome (HES). Data Sources Review of …

MATERIALS AND METHODS We performed a retrospective chart review of subjects with
CsU who underwent tST evaluation via fluorescent enzyme immunoassay from 2004 to 2011. …

Physical urticaria is considered a subgroup of chronic urticaria (CU) and is characterized by
lesions reproducibly triggered by physical stimuli, including cold, heat, physical pressure, …

Gastrointestinal (GI) symptoms have long been recognized in patients with systemic
mastocytosis. The attribution of GI symptoms in patients with clonal or monoclonal mast cell …