User profiles for George F. Muschler

George Muschler

Professor or Orthopaedic Surgery and Biomedical Engineering, Cleveland Clinic
Verified email at ccf.org
Cited by 15321

Bone graft materials: an overview of the basic science

TW Bauer, GF Muschler - Clinical Orthopaedics and Related …, 2000 - journals.lww.com
Autograft, allograft, and synthetic bone graft substitute materials play an important role in
reconstructive orthopaedic surgery, and understanding the biologic effects of these materials is …

Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions: a prospective, randomized clinical trial comparing rhOP-1 with fresh bone …

…, CR Perry, JD Cole, SD Cook, G Cierny, GF Muschler… - JBJS, 2001 - journals.lww.com
Background: The role of bone morphogenetic proteins (BMPs) in osseous repair has been
demonstrated in numerous animal models. Recombinant human osteogenic protein-1 (rhOP-…

Engineering principles of clinical cell-based tissue engineering

GF Muschler, C Nakamoto, LG Griffith - JBJS, 2004 - journals.lww.com
Tissue engineering is a rapidly evolving discipline that seeks to repair, replace, or regenerate
specific tissues or organs by translating fundamental knowledge in physics, chemistry, and …

Age‐and gender‐related changes in the cellularity of human bone marrow and the prevalence of osteoblastic progenitors

GF Muschler, H Nitto, CA Boehm… - Journal of orthopaedic …, 2001 - Wiley Online Library
Bone marrow harvested by aspiration contains connective tissue progenitor cells which can
be induced to express a bone phenotype in vitro. The number of osteoblastic progenitors …

Aspiration to obtain osteoblast progenitor cells from human bone marrow: the influence of aspiration volume

GF Muschler, C Boehm, K Easley - JBJS, 1997 - journals.lww.com
Bone marrow contains osteoblast progenitor cells that can be obtained with aspiration and
appear to arise from a population of pluripotential connective-tissue stem cells. When …

[PDF][PDF] Knee osteoarthritis: a primer

…, NS Piuzzi, ME Husni, GF Muschler… - The Permanente …, 2017 - thepermanentejournal.org
The purpose of this article is to provide a synopsis of the current medical understanding of
knee osteoarthritis. We describe the prevalence, causes and associated risk factors, symptoms…

A call for standardization in platelet-rich plasma preparation protocols and composition reporting: a systematic review of the clinical orthopaedic literature

…, AG Geeslin, IR Murray, GJ Dornan, GF Muschler… - JBJS, 2017 - journals.lww.com
Background: Platelet-rich plasma (PRP) is a blood-derived preparation whose use has grown
exponentially in orthopaedic practice. However, there remains an unclear understanding …

Bone cells and matrices in orthopedic tissue engineering

…, CN Cornell, GF Muschler - Orthopedic Clinics, 2000 - orthopedic.theclinics.com
The use of cells for the purpose of orthopedic tissue engineering started more than 300 years
ago. The first attempt of bone grafting was reported in 1668 by the Dutch surgeon Job Van …

Characterization of human bone marrow stromal cells with respect to osteoblastic differentiation

…, H Nitto, RJ Midura, GF Muschler - Journal of …, 1997 - Wiley Online Library
Human bone marrow was harvested by means of iliac crest aspiration and cultured under
conditions that promote an osteoblastic phenotype. Human bone marrow aspirates from 30 …

The design and use of animal models for translational research in bone tissue engineering and regenerative medicine

GF Muschler, VP Raut, TE Patterson… - … Engineering Part B …, 2010 - liebertpub.com
This review provides an overview of animal models for the evaluation, comparison, and
systematic optimization of tissue engineering and regenerative medicine strategies related to …