… Correspondence to: GH Guyatt, CLARITY Research Group, Department of Clinical
Epidemiology and Biostatistics, Room 2C12, 1200 Main Street, West Hamilton, ON, Canada …

This chapter addresses first one of the key aspects of interpreting findings that is also
fundamental in completing a ‘Summary of findings’ table: the certainty of evidence related to each …

A NEW paradigm for medical practice is emerging. Evidence-based medicine de-emphasizes
intuition, unsystematic clinical experience, and pathophysiologic rationale as sufficient …

The GRADE system classifies recommendations made in guidelines as either strong or
weak. This article explores the meaning of these descriptions and their implications for …

CLINICAL SCENARIO You are back where we put you in the previous article 1 on diagnostic
tests in this series on how to use the medical literature: in the library studying an article that …

CLINICAL SCENARIO You are working as an internal medicine resident in a rheumatology
rotation and are seeing a 19-year-old woman who has had systemic lupus erythematosus …

Objective To develop an evidence‐based guideline for the comprehensive management of
osteoarthritis ( OA ) as a collaboration between the American College of Rheumatology ( …

Objective To update the American College of Rheumatology (ACR) 2000 recommendations
for hip and knee osteoarthritis (OA) and develop new recommendations for hand OA. …

Objective To provide guidance for the management of gout, including indications for and
optimal use of urate‐lowering therapy ( ULT ), treatment of gout flares, and lifestyle and other …

In recent years quality of life instruments have been featured as primary outcomes in many
randomized trials. One of the challenges facing the investigator using such measures is …