Fru-2,6-P 2 (fructose 2,6-bisphosphate) is a signal molecule that controls glycolysis. Since its
discovery more than 20 years ago, inroads have been made towards the understanding of …

During liver development, hepatocytes and biliary cells differentiate from common progenitors
called hepatoblasts. The factors that control hepatoblast fate decision are unknown. Here …

An overview of glucocorticoid action is presented including aspects of historic, clinical, and
physiologic interest. Despite the diversity of effects, glucocorticoid hormone action at the …

It is becoming increasingly clear that signaling via G protein-coupled receptors is a diverse
phenomenon involving receptor interaction with a variety of signaling partners. Despite this …

Platelets have a crucial role in the maintenance of hemostasis as well as in thrombosis and
vessel occlusion, which underlie stroke and acute coronary syndromes. Anucleate platelets …

During liver development, hepatoblasts differentiate into hepatocytes or biliary epithelial cells
(BEC). The BEC delineate the intrahepatic and extrahepatic bile ducts, and the gallbladder…

Hepatocyte nuclear factor 6 (HNF-6) is the prototype of a new class of cut homeodomain
transcription factors. During mouse development, HNF-6 is expressed in the epithelial cells that …

Myocardial infarction (MI) in rats is accompanied by apoptosis in the limbic system and a
behavioural syndrome similar to models of depression. We have already shown that probiotics …

Hypercholesterolemia plays a causal role in the development of atherosclerosis and is one
of the main risk factors for cardiovascular disease (CVD), the leading cause of death …

The pancreas derives from cells in the ventral and dorsal foregut endoderm that express the
transcription factor Pdx-1. These specified cells give rise to the precursors of the endocrine, …