Rationale and objective: The present study tested the hypothesis that chronic interference by
cannabis with endogenous cannabinoid systems during peripubertal development causes …

Erythropoietin (EPO) promotes neuronal survival after hypoxia and other metabolic insults
by largely unknown mechanisms. Apoptosis and necrosis have been proposed as …

Using immunohistochemistry, expression of erythropoietin (EPO), a hypoxia-inducible
neuroprotective factor, and its receptor (EPOR) were investigated in human brain tissue after …

Understanding the control of myelin formation by oligodendrocytes is essential for treating
demyelinating diseases. Neuregulin-1 (NRG1) type III, an EGF-like growth factor, is essential …

Schizophrenia is increasingly recognized as a neurodevelopmental disease with an additional
degenerative component, comprising cognitive decline and loss of cortical gray matter. …

Background Erythropoietin (EPO) and its receptor play a major role in embryonic brain, are
weakly expressed in normal postnatal/adult brain and up-regulated upon metabolic stress. …

Endothelins are peptides, originally isolated from endothelial cells, with potent vasoactive
and mitogenic properties. In this study, we demonstrate that human macrophages synthesize …

Autism spectrum disorder (ASD) is a frequent neurodevelopmental disorder characterized
by variable clinical severity. Core symptoms are qualitatively impaired communication and …

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

Background and Purpose— Numerous preclinical findings and a clinical pilot study suggest
that recombinant human erythropoietin (EPO) provides neuroprotection that may be …