Ferroptosis is a necrotic form of regulated cell death (RCD) mediated by phospholipid
peroxidation in association with free iron-mediated Fenton reactions. Disrupted iron homeostasis …

Cigarette smoke (CS)-induced mitochondrial damage with increased reactive oxygen species
(ROS) production has been implicated in COPD pathogenesis by accelerating senescence…

Mitochondria are dynamic organelles that continuously change their shape through fission
and fusion. Disruption of mitochondrial dynamics is involved in disease pathology through …

Background Accumulation of profibrotic myofibroblasts in fibroblastic foci (FF) is a crucial
process for development of fibrosis during idiopathic pulmonary fibrosis (IPF) pathogenesis, …

Cigarette smoke (CS)–induced cellular senescence has been implicated in the pathogenesis
of chronic obstructive pulmonary disease, and SIRT6, a histone deacetylase, antagonizes …

Cigarette smoke (CS)-induced accumulation of mitochondrial damage has been widely
implicated in chronic obstructive pulmonary disease (COPD) pathogenesis. Mitophagy plays a …

Background Biomarkers for predicting the effect of anti–programmed cell death 1 (PD-1)
monoclonal antibody against non–small-cell lung cancer (NSCLC) are urgently required. …

Fibroblastic foci, known to be the leading edge of fibrosis development in idiopathic pulmonary
fibrosis (IPF), are composed of fibrogenic myofibroblasts. Autophagy has been implicated …

Background This study evaluated the safety, tolerability, pharmacokinetics, immunogenicity
and antitumor activity of single and multiple doses of nivolumab in Japanese patients with …

Accumulation of profibrotic myofibroblasts is involved in the process of fibrosis development
during idiopathic pulmonary fibrosis (IPF) pathogenesis. TGFB (transforming growth factor β) …