The influence of age on T cell generation and TCR diversity

…, J Fulbright, CM Weyand, JJ Goronzy - The Journal of …, 2005 - journals.aai.org
The ability to mount protective immune responses depends on the diversity of T cells. T cell
diversity may be compromised by the declining thymic output of new T cells. The aging …

[HTML][HTML] Understanding immunosenescence to improve responses to vaccines

JJ Goronzy, CM Weyand - Nature immunology, 2013 - nature.com
In the older adult, the benefits of vaccination to prevent infectious disease are limited, mainly
because of the adaptive immune system's inability to generate protective immunity. The age-…

Mechanisms underlying T cell ageing

JJ Goronzy, CM Weyand - Nature Reviews Immunology, 2019 - nature.com
T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human T …

T-cell–mediated lysis of endothelial cells in acute coronary syndromes

…, KJ Warrington, SL Kopecky, RL Frye, JJ Goronzy… - Circulation, 2002 - Am Heart Assoc
Background— CD4 T lymphocytes accumulate in unstable plaque. The direct and indirect
involvement of these T cells in tissue injury and plaque instability is not understood. Methods …

T cell subset-specific susceptibility to aging

…, ZZ Yang, JG Ouslander, CM Weyand, JJ Goronzy - Clinical …, 2008 - Elsevier
With increasing age, the competence of the immune system to fight infections and tumors
declines. Age-dependent changes have been mostly described for human CD8 T cells, raising …

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

…, M Tsang, E Krishnan, CM Weyand, JJ Goronzy - Nature medicine, 2012 - nature.com
The ability of the human immune system to respond to vaccination declines with age. We
identified an age-associated defect in T cell receptor (TCR)-induced extracellular signal–…

Medium-and large-vessel vasculitis

CM Weyand, JJ Goronzy - New England Journal of Medicine, 2003 - Mass Medical Soc
Giant-cell arteritis typically involves extracranial branches of the aorta, such as the temporal
and vertebral arteries. Temporal arteritis and polymyalgia rheumatica often coexist, and …

Lymphoid neogenesis in rheumatoid synovitis

…, RH Cofield, WM O'Fallon, JJ Goronzy… - The Journal of …, 2001 - journals.aai.org
In rheumatoid arthritis (RA), tissue-infiltrating lymphocytes can be arranged in sophisticated
organizations that resemble microstructures usually formed in secondary lymphoid organs. …

Diversity and clonal selection in the human T-cell repertoire

…, CM Weyand, SD Boyd, JJ Goronzy - Proceedings of the …, 2014 - National Acad Sciences
T-cell receptor (TCR) diversity, a prerequisite for immune system recognition of the universe
of foreign antigens, is generated in the first two decades of life in the thymus and then …

Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes

G Liuzzo, JJ Goronzy, H Yang, SL Kopecky… - Circulation, 2000 - Am Heart Assoc
Background—Unstable angina (UA) is associated with systemic inflammation and with
expansion of interferon-γ–producing T lymphocytes. The cause of T-cell activation and the …