Objective. —To examine whether cholesterol lowering with 3-hydroxy-3-methylglutaryl
coenzyme A (HMG-CoA) reductase inhibitors (statin drugs) reduces the risks of stroke and total …

Elevated plasma homocysteine levels have been associated with higher risks of cardiovascular
disease, but the effects on disease rates of supplementation with folic acid to lower …

PURPOSE: To assess the balance of benefits and risks of supplementation with beta-carotene,
vitamin E, vitamin C, and multivitamins on cancer, cardiovascular (CVD), and eye …

Context Secondary analyses of 2 randomized controlled trials and supportive epidemiologic
and preclinical data indicated the potential of selenium and vitamin E for preventing …

Context The initial report of the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
found no reduction in risk of prostate cancer with either selenium or vitamin E supplements …

Background Observational studies suggest that people who consume more fruits and
vegetables containing beta carotene have somewhat lower risks of cancer and cardiovascular …

Background Randomized trials have shown that low-dose aspirin decreases the risk of a first
myocardial infarction in men, with little effect on the risk of ischemic stroke. There are few …

Background It has been hypothesized that the pathogenesis of diseases induced by cigarette
smoking involves oxidative damage by free radicals. However, definitive evidence that …

ContextAlthough it has been hypothesized that hypertension is in part an inflammatory
disorder, clinical data linking inflammation with incident hypertension are scarce.ObjectiveTo …

ContextBasic research provides plausible mechanisms and observational studies suggest
that apparently healthy persons, who self-select for high intakes of vitamin E through diet or …