Objectives: To develop the European League Against Rheumatism (EULAR) recommendations
for conducting clinical studies and/or clinical trials in systemic vasculitis. Methods: An …

Objectives: We undertook a systematic literature review as a background to the European
League Against Rheumatism (EULAR) recommendations for conducting clinical trials in anti-…

The increasing prevalence of heart failure poses enormous challenges for health care systems
worldwide. Despite effective medical interventions that target neurohumoral activation, …

Background Cyclophosphamide induction regimens for antineutrophil cytoplasmic antibody
(ANCA)–associated vasculitis are effective in 70 to 90% of patients, but they are associated …

Background: The classification of antineutrophil cytoplasmic antibody-associated vasculitis (AAV)
and polyarteritis nodosa (PAN) for epidemiology studies is confusing. The existing …

Background Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a severe
condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly …

Background Respiratory tract infections may trigger relapses in patients with Wegener's
granu-lomatosis in remission. Uncontrolled data have suggested that treatment with trimethoprim…

Objective Prediction of relapses in Wegener's granulomatosis (WG) by measuring levels of
antineutrophil cytoplasmic antibodies (ANCA) directed against proteinase 3 (PR3) or …

Anti-neutrophil cytoplasmic antibodies (ANCAs) are valuable laboratory markers used for
the diagnosis of well-defined types of small-vessel vasculitis, including granulomatosis with …

Background In several autoimmune diseases, including multiple sclerosis (MS), a
compromised regulatory T cell (Treg) function is believed to be critically involved in the disease …