Geographic overlap between malaria and the occurrence of mutant hemoglobin and erythrocyte
surface proteins has indicated that polymorphisms in human genes have been selected …

In light of the recent controversies over the role of animal models for research into the
development of new treatments for severe malaria, particularly cerebral disease, a group of …

Infants and children are routinely vaccinated with bacillus Calmette-Guérin (BCG) in areas of
the world where worm infections are common. Because maternal helminth infection during …

In Papua New Guinea (PNG), numerous blood group polymorphisms and hemoglobinopathies
characterize the human population. Human genetic polymorphisms of this nature are …

Background. Available treatments for lymphatic filariasis (LF) are limited in their longterm
clearance of microfilaria from the blood. The safety and efficacy of a single-dose triple-drug …

Plasmodium vivax is a major public health burden, responsible for the majority of malaria
infections outside Africa. We explored the impact of demographic history and selective …

The current global initiative to eliminate lymphatic filariasis represents one of the largest mass
drug administration programmes ever conceived for the control of a parasitic disease. Yet, …

Individuals in areas of Plasmodium falciparum endemicity develop immunity to malaria after
repeated exposure. Knowledge of the acquisition and nature of protective immune …

The mechanistic basis for chloroquine resistance (CQR) in Plasmodium falciparum recently
has been linked to the polymorphic gene pfcrt. Alleles associated with CQR in natural …

Neonates exposed to parasite antigens (Ags) in utero may develop altered fetal immunity
that could affect subsequent responses to infection. We hypothesized that cord blood …