There is growing evidence from neuroimaging and ostmortem studies that severe mood
disorders, which have traditionally been conceptualized as neurochemical disorders, are …

This review aims to summarize the diverse proposed pathophysiological mechanisms
contributing to postpartum depression, highlighting both clinical and basic science research …

The lifetime risk for major depression in women is well known to be twice the risk in men
and is especially high during the reproductive years between menarche and menopause. A …

The changes in diagnostic criteria for major depressive disorder ( MDD ) from the fourth to
the fifth edition of the D iagnostic and S tatistical M anual of M ental D isorders ( DSM ) may …

BACKGROUND: The original serotonergic and noradrenergic hypotheses do not fully account
for the neurobiology of depression or mechanism of action of effective antidepressants. …

OBJECTIVE: This study was conducted to determine the efficacy and safety of riluzole, a
glutamate-modulating agent, in patients with recurrent major depression. METHOD: After a 1-…

Clinical studies over the past decades have attempted to uncover the biological factors
mediating the pathophysiology of bipolar disorder (BD) utilizing a variety of biochemical and …

Perinatal depression affects 10% to 20% of women in the United States during pregnancy,
the postpartum period, or both, but it can be difficult to recognize. Identifying and treating this …

Objective: Reliable identification of individuals at high risk for suicide is a priority for suicide
prevention. This study was conducted to identify genes exhibiting epigenetic variation …

Postpartum depression (PPD) affects∼ 10–18% of women in the general population and
results in serious consequences to both the mother and offspring. We hypothesized that …