Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy with manifestations of
hemolytic anemia, thrombocytopenia, and renal impairment. Genetic studies have shown that …

Based on preliminary evidence indicating that a cell-associated protein of U937 (a human
monocyte-like cell line) possessed cofactor activity and was not the C3b/C4b receptor, we …

The immune system must distinguish not only between self and non-self, but also between
innocuous and pathological foreign antigens to prevent unnecessary or self-destructive …

Age-related macular degeneration (AMD) is a leading cause of blindness in aged
individuals. Recent advances have highlighted the essential role of immune processes in the …

To define the role of rare variants in advanced age-related macular degeneration (AMD) risk,
we sequenced the exons of 681 genes within all reported AMD loci and related pathways …

Cytotoxic T lymphocytes and natural killer cells use the perforin/granzyme pathway to kill
virally infected cells and tumor cells. Mutations in genes important for this pathway are …

Hereditary angioedema is manifested by attacks of swelling of the extremities, face, trunk,
airway, or abdominal viscera, occurring spontaneously or secondary to trauma. It is inherited …

Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells use the perforin/granzyme pathway
as a major mechanism to kill pathogen-containing cells and tumor cells. Dysregulation of …

Complement components regularly become anchored to host cells as well as to microbes.
These components must be allowed to promote the reaction cascade on microbes but must …

The complement system has developed a remarkably simple but elegant manner of regulating
itself. It has faced and successfully dealt with how to facilitate activation on a microbe …