The most commonly prescribed oral anticoagulants worldwide are the vitamin K antagonists
(VKAs) such as warfarin. Factors affecting the pharmacokinetics of VKAs are important …

Genetics may account for much of the variability in our patients’ responses to drug therapies.
This article offers the clinician an up-to-date overview of pharmacogenomic testing, …

Statins are a cornerstone of the pharmacologic treatment and prevention of atherosclerotic
cardiovascular disease. Atherosclerotic disease is a predominant cause of mortality and …

Over recent decades, the demand for complementary and alternative medicine (CAM) has
continued to rise in the US. Like the practice of traditional Western medicine, CAM is …

Objective Simvastatin is primarily metabolized by CYP3A4. A combined CYP3A4/5
genotype classification, combining the decrease-of-function CYP3A4* 22 and the loss-of-function …

Purpose This study examined whether a CYP2D6 polymorphism (CYP2D6*4) was related
to beta-blocker maintenance dose in patients with heart failure. Methods Logistic regression …

Statin-induced myopathy (SIM) is the most common reason for discontinuation of statin
therapy. A polymorphism affecting the gene encoding glycine amidinotransferase (GATM …

Statins are the most commonly prescribed drugs in the United States and are extremely effective
in reducing major cardiovascular events in the millions of Americans with hyperlipidemia…

Indicated for treating hyperlipidemias and for the prevention of cardiovascular disease (CVD),
statins rank among the most commonly prescribed drug classes. While statins are …

Our objective was to evaluate the associations of genetic variants affecting simvastatin (SV)
and simvastatin acid (SVA) metabolism [the gene encoding cytochrome P450, family 3, …