OBJECTIVE: Bipolar spectrum disorders, which include bipolar I, bipolar II, and bipolar disorder
not otherwise specified, frequently go unrecognized, undiagnosed, and untreated. This …

The Canadian Network for Mood and Anxiety Treatments ( CANMAT ) previously published
treatment guidelines for bipolar disorder in 2005, along with international commentaries and …

Objective. —To compare the effectiveness of divalproex sodium with that of lithium and placebo
in patients with acute mania. Design. —Randomized, double-blind, parallel-group study …

Background: More treatment options for bipolar depression are needed. Currently available
antidepressants may increase the risk of mania and rapid cycling, and mood stabilizers …

OBJECTIVE: There is a major unmet need for effective options in the treatment of bipolar
depression. METHOD: Five hundred forty-two outpatients with bipolar I (N=360) or II (N=182) …

Background Episodes of depression are the most frequent cause of disability among patients
with bipolar disorder. The effectiveness and safety of standard antidepressant agents for …

Background Long-term outcomes are often poor in patients with bipolar disorder despite
treatment; more effective treatments are needed to reduce recurrences and morbidity. This …

Background Lamotrigine has been shown to be an effective treatment for bipolar
depression and rapid cycling in placebo-controlled clinical trials. This double-blind, placebo-controlled …

Primary depression can be associated with substantial hypercortisolism, thus prompting some
researchers to suggest that depression shares pathophysiologic features with Cushing's …

Background: The anticonvulsant lamotrigine was previously shown to be effective for bipolar
depression. This study assessed the efficacy and tolerability of lamotrigine and lithium …