Cell fate choice and commitment of multipotent progenitor cells to a differentiated lineage
requires broad changes of their gene expression profile. But how progenitor cells overcome …

The development of drug resistance, the prime cause of failure in cancer therapy, is
commonly explained by the selection of resistant mutant cancer cells. However, dynamic non-…

The developmental dynamics of multicellular organisms is a process that takes place in a
multi-stable system in which each attractor state represents a cell type, and attractor transitions …

Metformin is a biguanide drug that has been used to treat type 2 diabetes mellitus for more
than 60 years. The United Kingdom Prospective Diabetic Study (UKPDS) has shown …

Allergists and clinical immunologists around the world are increasingly faced with the task
of addressing drug allergy and hypersensitivity due to the increase in drug reactions. …

DR3 is a death domain-containing receptor that is upregulated during T cell activation and
whose overexpression induces apoptosis and NF-κB activation in cell lines. Here we show …

Understanding the mechanisms underlying autoantibody development will accelerate
therapeutic target identification in autoimmune diseases such as systemic lupus erythematosus (…

Despite the increasing interest in targeting stromal elements of the tumor microenvironment,
we still face tremendous challenges in developing adequate therapeutics to modify the …

Cell-type reprogramming, the artificial induction of a switch of cell lineage and developmental
stage, holds great promise for regenerative medicine. However, how does the metazoan …

We previously reported that joint swelling, synovial thickening, and cartilage matrix depletion
induced by the injection of anti-collagen monoclonal antibodies and lipopolysaccharide (…