Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common
genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic …

Automated computer-aided detection (CADe) has been an important tool in clinical practice
and research. State-of-the-art methods often show high sensitivities at the cost of high false-…

The mitochondrial theory of aging proposes that mitochondrial DNA (mtDNA) accumulates
mutations with age, and that these mutations contribute to physiological decline in aging and …

Genome-wide association studies have identified 32 loci influencing body mass index, but
this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-…

Background— Cardiac troponin I (cTnI) is a highly sensitive and specific marker for myocardial
injury that predicts outcomes in patients with acute coronary syndromes. Cardiovascular …

The protective mechanisms by which some obese individuals escape the detrimental metabolic
consequences of obesity are not understood. This study examined differences in body …

Automated classification of human anatomy is an important prerequisite for many computer-aided
diagnosis systems. The spatial complexity and variability of anatomy throughout the …

Despite tremendous progress in computer vision, there has not been an attempt to apply
machine learning on very large-scale medical image databases. We present an interleaved text/…

Background & Aims A common genetic variant near MBOAT7 (rs641738C>T) has been
previously associated with hepatic fat and advanced histology in NAFLD; however, these …

BACKGROUND: How serum albumin levels are associated with risk for heart failure (HF) in
the elderly is unclear. METHODS: We evaluated 2,907 participants without HF (age 73.6 ± …