Rationale: Evidence suggests that tumor necrosis factor (TNF)-α plays an important role in
the pathophysiology of sarcoidosis. Objectives: To assess the efficacy of infliximab in …

Eosinophils promote tissue injury and contribute to the pathogenesis of allergen-triggered
diseases like asthma, but the chemical basis of damage to eosinophil targets is unknown. We …

The aim of the present study was to investigate the efficacy of infliximab for the treatment of
extrapulmonary sarcoidosis. A prospective, randomised, double-blind, placebo-controlled …

Eosinophil recruitment and enhanced production of NO are characteristic features of asthma.
However, neither the ability of eosinophils to generate NO-derived oxidants nor their role in …

Sleep and its disorders are increasingly becoming important in our sleep deprived society.
Sleep is intricately connected to various hormonal and metabolic processes in the body and …

Objective: Recent studies suggest an association between chronic cough and gastroesophageal
reflux. Our study aims were 1) to define the prevalence of acid reflux induced cough in …

A wealth of evidence supports increased NO (NO ⋅ ) in asthma, but its roles are unknown.
To investigate how NO participates in inflammatory airway events in asthma, we measured …

Introduction Pulmonary alveolar proteinosis (PAP) is a rare disease of unknown etiology and
variable natural history. To date, the largest series from a single institution has consisted of …

Loss of superoxide dismutase activity occurs within minutes of an acute asthmatic response
to segmental antigen instillation into the lung of individuals with atopic asthma. Decreased …

Pulmonary alveolar proteinosis (PAP) is a rare idiopathic autoimmune lung disease in adults
characterized by the accumulation of lipoproteinaceous material within the alveoli of the …