Monoclonal antibodies preventing leukocyte activation reduce experimental neurologic injury and enhance efficacy of thrombolytic therapy

MP Bowes, R Rothlein, SC Fagan, JA Zivin - Neurology, 1995 - AAN Enterprises
Article abstract-We evaluated the ability of monoclonal antibodies directed against leukocyte
adhesion molecules (intercellular adhesion molecule-1 (ICAM-1), CD18) to enhance the …

Monoclonal antibody to the ICAM-1 adhesion site reduces neurological damage in a rabbit cerebral embolism stroke model

MP Bowes, JA Zivin, R Rothlein - Experimental neurology, 1993 - Elsevier
We evaluated the effect of antibodies directed against a leukocyte adhesion molecule (ICAM-1)
in an embolic model of stroke followed by thrombolysis with tissue plasminogen activator …

Screening for atrial fibrillation: sensitivity and specificity of a new methodology

M Lewis, D Parker, C Weston, M Bowes - British Journal of General Practice, 2011 - bjgp.org
There is no comprehensive screening programme for atrial fibrillation (AF) in either the UK
or the US. This paper describes a simple new technology that could contribute to such a …

Acute hypertension, but not thrombolysis, increases the incidence and severity of hemorrhagic transformation following experimental stroke in rabbits

MP Bowes, JA Zivin, GR Thomas, H Thibodeaux… - Experimental …, 1996 - Elsevier
Hemorrhagic transformation (HT) is a poorly understood yet frequent complication of stroke.
A transient increase in blood pressure (BP) occurs immediately after experimental …

Reduction of neurological damage by a peptide segment of the amyloid β/A4 protein precursor in a rabbit spinal cord ischemia model

MP Bowes, E Masliah, DAC Otero, JA Zivin… - Experimental …, 1994 - Elsevier
Although found as a precursor of Alzheimer amyloid, substantial evidence suggests that β/A4
protein precursor (APP) is involved in regulation of neuronal growth and survival. Recently, …

Acute hypertension promotes hemorrhagic transformation in a rabbit embolic stroke model: effect of labetalol

SC Fagan, MP Bowes, PD Lyden, JA Zivin - Experimental neurology, 1998 - Elsevier
We examined the relationship between acute hypertension following cerebral embolization
and subsequent hemorrhagic transformation (HT) in a rabbit embolic stroke model. We have …

Diaspirin cross-linked hemoglobin improves neurological outcome following reversible but not irreversible CNS ischemia in rabbits.

MP Bowes, KE Burhop, JA Zivin - Stroke, 1994 - Am Heart Assoc
Hemodilution using modified hemoglobin solutions may reduce ischemic central nervous
system injury. Purified diaspirin cross-linked hemoglobin (DCLHb) is a cell-free hemoglobin …

Combination treatment for acute ischemic stroke: A ray of Hope?

SC Fagan, MP Bowes, SA Berri, JA Zivin - Journal of Stroke and …, 1999 - Elsevier
Background: With the implementation of thrombolysis, a large number of distinct pharmacological
agents are now under consideration for the treatment of acute ischemic stroke, with …

Continuous intrathecal fluid infusions elevate nerve growth factor levels and prevent functional deficits after spinal cord ischemia

M Bowes, MH Tuszynski, J Conner, JA Zivin - Brain research, 2000 - Elsevier
Continuous intracerebroventricular or intrathecal infusions of neurotrophic factors have
been reported to prevent neuronal degeneration, stimulate axonal sprouting and ameliorate …

Morphine hyperalgesic effects on developmental changes in thermal nociception and respiration in domestic fowl (Gallus gallus)

RA Hughes, M Bowes, KJ Sufka - Pharmacology Biochemistry and …, 1992 - Elsevier
Domestic fowl tested at 3, 5, and 7 days posthatch jumped from a heated grid more rapidly
than animals tested at 14 days posthatch. Morphine (2.5 mg/kg) decreased jump latency in 14-…