User profiles for Melanie L. Yarbrough

Melanie Yarbrough

Associate Professor, Washington University School of Medicine
Verified email at wustl.edu
Cited by 1945

AMPylation of Rho GTPases by Vibrio VopS Disrupts Effector Binding and Downstream Signaling

ML Yarbrough, Y Li, LN Kinch, NV Grishin, HL Ball… - science, 2009 - science.org
The Vibrio parahaemolyticus type III effector VopS is implicated in cell rounding and the
collapse of the actin cytoskeleton by inhibiting Rho guanosine triphosphatases (GTPases). We …

Arp2/3-independent assembly of actin by Vibrio type III effector VopL

…, JE Trosky, DW Leung, ML Yarbrough… - Proceedings of the …, 2007 - National Acad Sciences
Microbial pathogens use a variety of mechanisms to disrupt the actin cytoskeleton during
infection. Vibrio parahaemolyticus (V. para) is a Gram-negative bacterium that causes …

Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and then cell lysis

DL Burdette, ML Yarbrough… - Proceedings of the …, 2008 - National Acad Sciences
The bacterial pathogen Vibrio parahaemolyticus utilizes a type III secretion system to cause
death of host cells within hours of infection. We report that cell death is completely …

Viral subversion of nucleocytoplasmic trafficking

ML Yarbrough, MA Mata, R Sakthivel, BMA Fontoura - Traffic, 2014 - Wiley Online Library
Trafficking of proteins and RNA into and out of the nucleus occurs through the nuclear pore
complex ( NPC ). Because of its critical function in many cellular processes, the NPC and …

[HTML][HTML] Fido, a novel AMPylation domain common to fic, doc, and AvrB

LN Kinch, ML Yarbrough, K Orth, NV Grishin - PloS one, 2009 - journals.plos.org
Background The Vibrio parahaemolyticus type III secreted effector VopS contains a fic domain
that covalently modifies Rho GTPase threonine with AMP to inhibit downstream signaling …

[HTML][HTML] Primate-specific miR-576-3p sets host defense signalling threshold

ML Yarbrough, K Zhang, R Sakthivel, CV Forst… - Nature …, 2014 - nature.com
MicroRNAs (miRNAs) have been shown to regulate viral infection, but the miRNAs that target
intracellular sensors and adaptors of innate immunity have not been fully uncovered. Here …

Epidemiology, clinical characteristics, and antimicrobial susceptibility profiles of human clinical isolates of Staphylococcus intermedius group

ML Yarbrough, W Lainhart… - Journal of clinical …, 2018 - Am Soc Microbiol
The veterinary pathogens in the Staphylococcus intermedius group (SIG) are increasingly
recognized as causes of human infection. Shared features between SIG and Staphylococcus …

The ABCs of STIs: an update on sexually transmitted infections

ML Yarbrough, CAD Burnham - Clinical chemistry, 2016 - academic.oup.com
BACKGROUND Sexually transmitted infections (STIs) are spread primarily through sexual
contact and are a major cause of morbidity and mortality worldwide. Once identified, some …

Impact of total laboratory automation on workflow and specimen processing time for culture of urine specimens

ML Yarbrough, W Lainhart, AR McMullen… - European Journal of …, 2018 - Springer
Total laboratory automation (TLA) has the potential to reduce specimen processing time,
improve standardization of cultures, and decrease turnaround time (TAT). The objective of this …

Evaluation of genotypic and phenotypic methods to detect carbapenemase production in Gram-negative bacilli

AR McMullen, ML Yarbrough, MA Wallace… - Clinical …, 2017 - academic.oup.com
BACKGROUND Carbapenemase-producing gram-negative bacteria (CP-GNB) are an urgent
and expanding public health threat. Rapid and accurate identification of these organisms …