Colorectal polyps are the precursors for most colorectal cancers (CRCs). Some colorectal
polyps accumulate enough mutations to develop high-grade dysplasia and eventual invasion …

We examined the immune microenvironment of primary colorectal cancer using
immunohistochemistry, laser capture microdissection/qRT-PCR, flow cytometry, and functional …

The highest cancer risks in familial adenomatous polyposis (FAP) include colorectal, duodenal,
and thyroid for which surveillance is recommended. Nearly all patients with FAP have …

Background Caroli’s disease is a rare congenital condition characterized by non-obstructive
dilatation of intrahepatic ducts. In Caroli’s syndrome, there is additionally an associated …

Transducer-like enhancer of split 1 (TLE1) is overexpressed in synovial sarcomas. We
investigated TLE1 expression by immunohistochemical analysis in a well-characterized series of …

Hepatitis B virus, hepatitis C virus, autoimmune hepatitis, and nonalcoholic fatty liver disease
can induce chronic liver disease. The Programmed Death‐1 (PD‐1) inhibitory pathway …

Patients with familial adenomatous polyposis (FAP), an autosomal dominant cancer
predisposition syndrome caused by mutations in the APC gene, develop neoplasms in both the …

The pathogenesis of ulcerative colitis (UC), a major type of inflammatory bowel disease,
remains unknown. No model exists that adequately recapitulates the complexity of clinical UC. …

Fibrolamellar carcinoma has a distinctive morphology and immunophenotype, including
cytokeratin 7 and CD68 co-expression. Despite the distinct findings, accurate diagnosis of …

Neutropenic enterocolitis (NE) is a deadly ileocecal-based disease seen in patients with a
recent history of chemotherapy. As histology is not included in the current diagnostic criteria, …