Genome-wide association studies have identified SNPs within FTO, the human fat mass and
obesity–associated gene, that are strongly associated with obesity. Individuals homozygous …

As the human genome project approaches completion, the challenge for mammalian geneticists
is to develop approaches for the systematic determination of mammalian gene function. …

We identified two novel mouse mutants with abnormal head-shaking behavior and neural
tube defects during the course of independent ENU mutagenesis experiments. The …

One component of the circadian clock in mammals is the Clock-Bmal1 heterodimeric transcription
factor. Among its downstream targets, two genes, Cry1 and Cry2, encode inhibitors of …

By screening N-ethyl-N-nitrosourea–mutagenized animals for alterations in rhythms of
wheel-running activity, we identified a mouse mutation, after hours (Afh). The mutation, a Cys 358 …

Background: Obesity is one of the leading causes of preventable death worldwide. Circadian
rhythms are known to control both sleep timing and energy homeostasis, and disruptions in …

The most well-described example of an inherited speech and language disorder is that observed
in the multigenerational KE family, caused by a heterozygous missense mutation in the …

Establishing standard operating procedures (SOPs) as tools for the analysis of behavioral
phenotypes is fundamental to mouse functional genomics. It is essential that the tests …

Progress in unravelling the cellular and molecular basis of mammalian circadian regulation
over the past decade has provided us with new avenues through which we can explore …

The hereditary ataxias are a complex group of neurological disorders characterized by the
degeneration of the cerebellum and its associated connections. The molecular mechanisms …