There is a paucity of therapies for most neurological disorders—from rare lysosomal storage
diseases to major public health concerns such as stroke and Alzheimer's disease. …

Alzheimer's disease (AD) is an age-related disorder characterized by progressive cognitive
decline and dementia. Alzheimer's disease is an increasingly prevalent disease with 5.3 …

Vitamin E (α-tocopherol or αT) has long been recognized as a classic free radical scavenging
antioxidant whose deficiency impairs mammalian fertility. In actuality, α-tocopherol is one …

In Alzheimer’s disease (AD) inflammatory processes occur in pathologically vulnerable
brain regions. The objective of this study is to compare both the release and the presence of …

The last decade has seen a substantial increase in research focused on the identification of
blood-based biomarkers that have utility in Alzheimer's disease (AD). Blood-based …

Recent data indicate that certain pro-inflammatory cytokines are transcriptionally upregulated
in the spinal cords of G93A-SOD1 mice, a model of amyotrophic lateral sclerosis (ALS). We …

The lack of readily available biomarkers is a significant hindrance toward progressing to
effective therapeutic and preventative strategies for Alzheimer's disease (AD). Blood-based …

The cerebral microcirculation undergoes specific biochemical changes in Alzheimer′s
disease. In this study, we have compared the nitric oxide synthase (NOS) activity of brain …

Diseases of the central nervous system (CNS) pose a significant health challenge, but
despite their diversity, they share many common features and mechanisms. For example, …

The notion that microvascular abnormalities contribute to deleterious changes in the Alzheimer's
disease (AD) brain is supported by work from our laboratory and others demonstrating …