In earlier studies, we concluded that biliary cholesterol supersaturation may be a necessary
but not sufficient cause for gallstone formation. In the present studies, we calculated …

The development and validation of a direct method for measuring maximum cholesterol
solubility in bile is described. Application of this method to five large mammalian species, …

Apolipoproteins A-1 and A-2 were purified from human plasma. At concentrations present in
human bile these proteins prolonged the nucleation time of cholesterol monohydrate …

The presence of small vesicles composed of phospholipid and cholesterol has recently been
demonstrated in super-saturated model and in dilute native human biles by several groups …

Three generations of a kindred comprising 50 individuals are described in which recurrent
intrahepatic cholestasis of pregnancy has occurred with high frequency. A uniform expression …

Discrepancies have existed regarding the correlation between raised bile acid levels in
cholestasis and the presence of pruritus. Nevertheless, the prevalent view is that bile acids have …

Supersaturation is a necessary precondition to the thermodynamic destabilization of bile
and thus to the eventual crystallization of cholesterol that leads to gallstone formation. The …

Background: About 50% of populations in developed countries have bile supersaturated
with cholesterol, which is a major risk factor for cholesterol gallstone formation. Despite the …

Background/Aims: We have recently outlined the biochemical features of a human 42-kilodalton
biliary glycoprotein that shows concentration-dependent cholesterol crystallization-…

WJ Claffey and RT Holzbach* abstract: We investigated the dependence of certain prop-erties
of bile salt/lecithin mixed micelles on the molar ratio of the two components. UV …