Drug-induced lung disease presents several diagnostic and therapeutic problems to the
clinician. This is especially true in the case of lung disease associated with antirheumatic …

IL-6 is a multi-functional cytokine that plays an important role in normal biologic homeostasis
and disease pathogenesis. Retinoids are vitamin A analogs that regulate the function of a …

The start of the field of cytokine biology has been variously dated to 1951 with the discovery
of nerve growth factor, 1954 with the discovery of interferon, the 1960s with the first …

… of SLPI can be deregu2 Address correspondence to Ralph J. Zitnik, MD, Division of Pul- …
tory region of the mSLPI gene (Zitnik RJ, et al., manu- lowercase. Residues at which …

We characterized the effects of agents that alter intracellular adenosine 3',5'-cyclic monophosphate
(cAMP) on the interleukin (IL)-6 production of human lung fibroblasts. Unstimulated …

Interleukin (IL)-6 is a pleiotropic cytokine produced by a wide variety of cells including
fibroblasts, macrophages, endothelial cells, and T and B lymphocytes. Regulated IL-6 production …

Implantable medical devices are finding increasing use in the treatment of diseases traditionally
targeted with drugs. It is well established that the cholinergic anti-inflammatory pathway …

Human secretory leukocyte protease inhibitor (SLPI) is a predominant physiologic inhibitor
of elastase and cathepsin G, proinflammatory serine proteases released by activated …

Interleukin-6 (IL-6) was discovered as a result of independent investigations by numerous
laboratories on what appeared to be discrete biological activities. In 1980, it was appreciated …

The lung is a common target of drug toxicity. A variety of medications, including cancer
chemotherapeutic drugs, anti-inflammatory medications, antimicrobial agents, cardiac drugs and …