Background— The extent of the peri-infarct zone by magnetic resonance imaging (MRI) has
been related to all-cause mortality in patients with coronary artery disease. This relationship …

The requirement of chemical energy in the form of ATP to support systolic and diastolic work
of the heart is absolute. Because of its central role in cardiac metabolism and performance, …

Objectives : We examined whether the presence and extent of late gadolinium enhancement
(LGE) by cardiovascular magnetic resonance (CMR) predict adverse outcomes in …

The heart consumes more energy per gram than any other organ, and the creatine kinase (CK)
reaction serves as its prime energy reserve. Because chemical energy is required to fuel …

Objectives : This study tested the hypothesis that acute administration of the xanthine
oxidase (XO) inhibitor allopurinol improves cardiac high-energy phosphate concentrations in …

Background— Patients with left ventricular dysfunction have an elevated risk of sudden
cardiac death. However, the substrate for ventricular arrhythmia in patients with nonischemic …

Background— Magnetic resonance imaging (MRI) is an important diagnostic modality
currently unavailable for millions of patients because of the presence of implantable cardiac …

Background. The maintenance of cellular levels of high-energy phosphates is required for
myocardial function and preservation. In animals, severe myocardial ischemia is …

Myocardial high-energy phosphate metabolism in patients with dilated cardiomyopathy (DCM)
of ischemic or idiopathic etiology was assessed at rest by one-dimensional phase-…

Objectives : We tested a circumferential mechanical dyssynchrony index (circumferential
uniformity ratio estimate [CURE]; 0 to 1, 1 = synchrony) derived from magnetic resonance-…