[HTML][HTML] Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human FcγRIII and antibody-dependent cellular toxicity

RL Shields, J Lai, R Keck, LY O'Connell, K Hong… - Journal of Biological …, 2002 - ASBMB
Lec13 cells, a variant Chinese hamster ovary cell line, were used to produce human IgG1
that were deficient in fucose attached to the Asn 297 -linked carbohydrate but were otherwise …

[HTML][HTML] High resolution mapping of the binding site on human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and design of IgG1 variants with improved binding to the FcγR

RL Shields, AK Namenuk, K Hong, YG Meng… - Journal of Biological …, 2001 - ASBMB
Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated
immune responses with cellular effector functions. A high resolution map of the binding site on …

[BOOK][B] Cultures of the Internet: Virtual spaces, real histories, living bodies

RM Shields, R Shields - 1996 - books.google.com
The Internet is here but have we caught up with all the implications for culture and everyday
life? This collection of original articles on the development of computer-mediated …

Structural controllability of multiinput linear systems

R Shields, J Pearson - IEEE Transactions on Automatic control, 1976 - ieeexplore.ieee.org
This paper extends the results of Lin on structural controllability of single-input linear systems
to multiinput linear systems. An interesting byproduct of this extension is an application of …

Expression of full-length immunoglobulins in Escherichia coli: rapid and efficient production of aglycosylated antibodies

…, TS Raju, G Meng, P Sims, K Hong, RL Shields… - Journal of …, 2002 - Elsevier
Many research and clinical applications require large quantities of full-length antibodies with
long circulating half-lives, and production of these complex multi-subunit proteins has in the …

Accurate Predictions of Water Cluster Formation, (H2O)n=2−10

RM Shields, B Temelso, KA Archer… - The Journal of …, 2010 - ACS Publications
An efficient mixed molecular dynamics/quantum mechanics model has been applied to the
water cluster system. The use of the MP2 method and correlation consistent basis sets, with …

Determination of protein-bound carbohydrate in serum by modified anthrone method

R Shields, W Burnett - Analytical Chemistry, 1960 - ACS Publications
Sir: The accurate determination of serum protein-bound carbohydrate by the anthrone
method (S) is hindered by the simultaneous release of tryptophan from the protein (5-7). …

[PDF][PDF] Heart rate variability with deep breathing as a clinical test of cardiovagal function

RW Shields - Cleve Clin J Med, 2009 - academia.edu
Research into heart rate variability (HRV) and respiration over the past 150 years has led to
the insight that HRV with deep breathing (HRVdb) is a highly sensitive measure of …

The binding site on human immunoglobulin E for its high affinity receptor

L Presta, R Shields, L O'Connell, S Lahr, J Porter… - Journal of Biological …, 1994 - ASBMB
Immunoglobulin (Ig) E antibodies mediate allergic responses by binding to specific high
affinity receptors, Fc epsilon RI, on mast cells and basophils. Previous studies have shown that …

Functional anatomy of the autonomic nervous system

RW Shields Jr - Journal of clinical Neurophysiology, 1993 - journals.lww.com
The autonomic nervous system (ANS) via its sympathetic and parasympathetic divisions
influences the function of nearly all organ systems. Via autonomic reflexes, the ANS is …