Atherosclerosis is an inflammatory disease. Because high plasma concentrations of cholesterol,
in particular those of low-density lipoprotein (LDL) cholesterol, are one of the principal …

Atherosclerosis, the principal cause of heart attack, stroke and gangrene of the extremities,
is responsible for 50% of all mortality in the USA, Europe and Japan. The lesions result from …

Smooth muscle derived from the inner media and intima of immature guinea pig aorta were
grown for up to 8 wk in cell culture. The cells maintained the morphology of smooth muscle at …

CARDIOVASCULAR disease remains the chief cause of death in the United States and
Western Europe, and atherosclerosis, the principal cause of myocardial and cerebral infarction, …

Atherosclerosis is an arterial disease that is recognized to be the chief cause of death in the
United States and in Western Europe. Its importance as a principal cause of myocardial and …

Cell proliferation and directed cell movement are key events in several normal processes
including embryogenesis and development, responses to injury such as wound repair, and in …

The Response-to-Injury Hypothesis The response-to-injury hypothesis dates back to the
pioneering work of Virchow. Since then, it has been modified and extended by many …

We postulate that the lesions of atherosclerosis arise as a result of some form of" injury" to
arterial endothelium. This injury somehow results in alteration in endothelial cell-cell …

Dialyzed serum from clotted monkey blood (“blood serum”) promotes the proliferation of
monkey arterial smooth muscle cells in culture, but dialyzed serum prepared from recalcified …

To appreciate the role of the arterial smooth muscle cell in atherosclerosis, it is necessary to
know something about the structure of normal arteries. Normal arteries are composed of …