Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines
The emergence of novel and evolving variants of SARS-CoV-2 has fostered the need for
change in the form of newer and more adaptive diagnostic methods for the detection of SARS-…
change in the form of newer and more adaptive diagnostic methods for the detection of SARS-…
[HTML][HTML] Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance
The tumor microenvironment represents a complex network, in which tumor cells not only
communicate with each other but also with stromal and immune cells. Current research has …
communicate with each other but also with stromal and immune cells. Current research has …
[HTML][HTML] CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances
In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a
promising immunotherapeutic approach to fight cancers. This approach consists of genetically …
promising immunotherapeutic approach to fight cancers. This approach consists of genetically …
Ownership structure and corporate financial performance in an emerging market: a dynamic panel data analysis
… Shahab Ud Din (Department of Business Management, Karakoram International
University Gilgit-Baltistant, Gilgit, Pakistan) … Din, SU, Arshad Khan, M., Khan, MJ and Khan …
University Gilgit-Baltistant, Gilgit, Pakistan) … Din, SU, Arshad Khan, M., Khan, MJ and Khan …
[HTML][HTML] Tight junction proteins and signaling pathways in cancer and inflammation: a functional crosstalk
The ability of epithelial cells to organize through cell–cell adhesion into a functioning
epithelium serves the purpose of a tight epithelial protective barrier. Contacts between adjacent …
epithelium serves the purpose of a tight epithelial protective barrier. Contacts between adjacent …
[HTML][HTML] Integrative toxicogenomics: Advancing precision medicine and toxicology through artificial intelligence and OMICs technology
More information about a person's genetic makeup, drug response, multi-omics response,
and genomic response is now available leading to a gradual shift towards personalized …
and genomic response is now available leading to a gradual shift towards personalized …
Role of phosphatidylinositol 3′-kinase/AKT pathway in diffuse large B-cell lymphoma survival
S Uddin, AR Hussain, AK Siraj, PS Manogaran… - Blood, 2006 - ashpublications.org
Phosphatidylinositol 3′-kinase (PI3K) is a key player in cell-growth signaling in a number of
lymphoid malignancies, but its role in diffuse large B-cell lymphoma (DLBCL) has not been …
lymphoid malignancies, but its role in diffuse large B-cell lymphoma (DLBCL) has not been …
[HTML][HTML] Role of miRNA-regulated cancer stem cells in the pathogenesis of human malignancies
…, EI Ahmed, NR Elareer, K Junejo, M Steinhoff, S Uddin - Cells, 2019 - mdpi.com
Recent biomedical discoveries have revolutionized the concept and understanding of
carcinogenesis, a complex and multistep phenomenon which involves accretion of genetic, …
carcinogenesis, a complex and multistep phenomenon which involves accretion of genetic, …
[HTML][HTML] Protein kinase C-δ (PKC-δ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727
It is well established that engagement of the Type I interferon (IFN) receptor results in activation
of JAKs (Janus kinases), which in turn regulate tyrosine phosphorylation of STAT proteins…
of JAKs (Janus kinases), which in turn regulate tyrosine phosphorylation of STAT proteins…
[HTML][HTML] Activation of the p38 mitogen-activated protein kinase by type I interferons
S Uddin, B Majchrzak, J Woodson, P Arunkumar… - Journal of Biological …, 1999 - ASBMB
The p38 mitogen-activated protein (Map) kinase plays a critical role in the generation of
signals in response to stress stimuli, but its role in interferon (IFN) signaling and its potential …
signals in response to stress stimuli, but its role in interferon (IFN) signaling and its potential …