The hormone progesterone is readily converted to 3α-OH-5α-pregnan-20-one (3α,5α-THP)
in the brains of males and females 1 , 2 . In the brain, 3α,5α-THP acts like a sedative 3 , 4 , 5 , …

In the present study, we have characterized properties of steroid withdrawal using a
pseudopregnant rat model. This paradigm results in increased production of endogenous …

Here we report that low concentrations of alcohol (1–3 mM) increased Cl − currents gated by
a recombinant GABA A receptor, α 4 β 2 δ, by 40–50% in Xenopus laevis oocytes. We also …

Puberty is characterized by mood swings and anxiety, which are often produced by stress.
Here we show that THP (allopregnanolone), a steroid that is released as a result of stress, …

Neurosteroids, such as the progesterone metabolite 3α-OH-5α[β]-pregnan-20-one (THP or [allo]pregnanolone),
function as potent positive modulators of the GABA A receptor (GABAR) …

In this study, the neuromodulatory effects of progesterone were tested in an intact neuronal
circuit of a model extrahypothalamic CNS area. Spontaneous discharge and responses of …

The onset of puberty defines a developmental stage when some learning processes are
diminished, but the mechanism for this deficit remains unknown. We found that, at puberty, …

2.1. 1. Psychotropic actions 2.1. 2. Effects on seizure activity 2.1. 3. Effects on locomotor activity
2.1. 3.1. Sex differences in organizational vs activational effects of estradiol 2.1. 3.2. Limb …

In this study, 48h administration of 3α-OH-5β-pregnan-20-one (3α,5β-THP) or 17β-estradiol (E
2 )+progesterone (P) to female rats increased expression of the δ subunit of the GABA A …

■ ABSTRACT The steroid hormones 17β-estradiol (estradiol) and progesterone not only
regulate the reproductive system but have other central nervous system effects that can directly …