Angiotensin-converting enzyme (ACE) inhibition alone or in combination with the angiotensin
type-I receptor (AT 1 ) antagonist losartan augments circulating levels of the bioactive …

We determined the mechanism accounting for the removal and metabolism of angiotensin-(1–7)
[Ang-(1–7)] in 21 anesthetized spontaneously hypertensive (SHR), 18 age-matched …

Blockade of angiotensin II (Ang II) function during 8 days of oral therapy with lisinopril (20
mg/kg) and losartan (10 mg/kg) normalized the arterial pressure (112±3/70±3 mm Hg) and …

Accumulating evidence suggests that angiotensin-(1-7) is an important component of the
renin-angiotensin system, having actions that are either identical to or opposite that of …

Accumulating evidence suggests that angiotensin-(1–7) [Ang-(1–7)] is an important component
of the renin–angiotensin system. As the most pleiotropic metabolite of angiotensin I (Ang I…

The renin-angiotensin system plays a crucial role in the development and establishment of
the hypertensive state in the spontaneously hypertensive (SH) rat. Interruption of this system's …

Prostaglandins are known to participate in the antihypertensive actions of angiotensin-converting
enzyme (ACE) inhibition and angiotensin type I (AT 1)-receptor antagonism. Because …

We exposed 63 adult spontaneously hypertensive rats (SHR) and 10 (mRen-2)27 transgenic
hypertensive rats to a 12-day regimen of either a normal diet (0.5%) or a low-salt diet (0.05…

The calcium channel blockers verapamil (VPM) and nimodipine (NMD) were administered to
adult or immature (16‐day‐old) rats to determine their effects on amygdala‐kindled seizures…

The purpose of this study was to evaluate the role of angiotensin II (AII) in fructose-treated rats
by assessing the effects of acute and chronic losartan treatment on glucose tolerance and …