PURPOSE: Drug-eluting stents are commonly used for percutaneous coronary intervention.
Despite excellent clinical efficacy, the association between drug-eluting stents and the risk …

Dendritic spines are micron-sized membrane protrusions receiving most excitatory synaptic
inputs in the mammalian brain. Spines form and grow during long-term potentiation (LTP) of …

L-type calcium channels couple membrane depolarization in neurons to numerous
processes including gene expression, synaptic efficacy, and cell survival. To establish the …

Endocytosis of AMPA receptors and other postsynaptic cargo occurs at endocytic zones (EZs),
stably positioned sites of clathrin adjacent to the postsynaptic density (PSD). The tight …

N-type calcium channels are critical for pain transduction. Inhibitors of these channels are
powerful analgesics, but clinical use of current N-type blockers remains limited by undesirable …

Neuronal L-type calcium channels are essential for regulating activity-dependent gene
expression, but they are thought to open too slowly to contribute to action potential-dependent …

Following synthesis, integral membrane proteins dwell in the endoplasmic reticulum (ER)
for variable periods that are typically rate limiting for plasma membrane delivery. In neurons, …

Mutations in the PARK2 gene cause hereditary Parkinson disease (PD). The PARK2 gene
product, termed parkin, is an E3 ubiquitin ligase that mediates the transfer of ubiquitin onto …

Objectives : This study investigated the risk of stent thrombosis associated with the use of
paclitaxel-eluting stents (PES) compared to bare-metal stents (BMS). Background : Clinical …

Phosphatidylinositol-4,5-bisphosphate (PIP 2 ) has been shown to regulate many ion channels,
transporters, and other signaling proteins, but it is not known whether it also regulates …