Background Ultrasound (US)-guided percutaneous needle biopsy is a useful diagnostic
technique with short examination time and real-time monitoring at the bedside. However, there …

We retrospectively investigated the impact of the tumor microenvironment ( TME ) on the
efficacy of epidermal growth factor receptor ( EGFR )‐tyrosine kinase inhibitors ( TKI s) as first‐…

Background Renal toxicity is a clinical problem that affects 28 − 42% of patients undergoing
treatment with cisplatin. Renal toxicity can be minimized by high volume hydration with …

Background Differences in carcinogenesis and therapeutic efficacy according to ethnicity have
been reported for lung cancer, and understanding differences in genetic mutation profiles …

Background Rash, liver dysfunction, and diarrhea are known major adverse events associated
with erlotinib and gefitinib. However, clinical trials with gefitinib have reported different …

Multiple primary lung cancers (MPLCs) harbour various genetic profiles among the tumours,
even from individuals with same non-intrinsic risk factors. Paired mutational analyses were …

Background Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs),
routinely used to treat advanced non-small-cell lung cancer (NSCLC) patients with activated …

Introduction Multiple primary lung cancers (MPLCs) occur in common carcinogenetic risks
such as lifestyle, biological aging, immune responses, hormones, and metabolism. Although …

Hepatocyte growth factor induces resistance to epidermal growth factor receptor tyrosine
kinase inhibitors. It has been hypothesized that epidermal growth factor receptor tyrosine …

Background The rate of lung cancer metastasis to the bone is high and skeletal-related
events (SREs) decrease the quality of life in many patients. Recently, it was found that a …