Aim The “2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease”
provides recommendations to guide clinicians in the diagnosis, genetic evaluation and family …

Background The cardiovascular safety of testosterone-replacement therapy in middle-aged
and older men with hypogonadism has not been determined. Methods In a multicenter, …

Background— An anomalous coronary artery from the opposite sinus of Valsalva may
increase sudden death risk in children and young adults, and surgical intervention is often …

Background Testosterone exerts some effects on the cardiovascular system that could be
considered beneficial; some other effects may potentially increase the risk of cardiovascular (…

Background Data regarding the risk of aortic dissection in patients with bicuspid aortic valve
and large ascending aortic diameter are limited, and appropriate timing of prophylactic …

Background We sought to study the impact of surgical intervention on long-term outcomes in
bicuspid aortic valve (BAV) patients who develop aortic valvular complications and/or have …

Background: In patients with a dilated proximal ascending aorta and trileaflet aortic valve,
we aimed to assess (1) factors independently associated with increased long-term mortality …

Background Improvements in care have prolonged survival of patients with connective tissue
disorders (CTDs), but their entire native aorta remains at risk. Little data are available to …

Objectives To assess intermediate-term outcomes of aortic root replacement with valve-sparing
reimplantation of bicuspid aortic valves (BAV), compared with tricuspid aortic valves (TAV…

Background— In patients with bicuspid aortic valve and dilated proximal ascending aorta, we
sought to assess (1) factors associated with increased longer-term cardiovascular mortality …