Background In patients with stable coronary artery disease, it remains unclear whether an
initial management strategy of percutaneous coronary intervention (PCI) with intensive …

Background Dual antiplatelet therapy with clopidogrel plus low-dose aspirin has not been
studied in a broad population of patients at high risk for atherothrombotic events. Methods We …

Background— Extent and severity of myocardial ischemia are determinants of risk for patients
with coronary artery disease, and ischemia reduction is an important therapeutic goal. The …

Background Among patients with stable coronary disease and moderate or severe ischemia,
whether clinical outcomes are better in those who receive an invasive intervention plus …

Background The cardiovascular safety of testosterone-replacement therapy in middle-aged
and older men with hypogonadism has not been determined. Methods In a multicenter, …

Background The effect of intensified platelet inhibition for patients with unstable angina or
myocardial infarction without ST-segment elevation who do not undergo revascularization has …

Background Non–Q-wave myocardial infarction is usually managed according to an “invasive”
strategy (ie, one of routine coronary angiography followed by myocardial revascularization…

ContextPatients with unstable angina or non–ST-segment elevation myocardial infarction (NSTEMI)
can be cared for with a routine invasive strategy involving coronary angiography …

Objectives : The purpose of this study was to determine the possible benefit of dual antiplatelet
therapy in patients with prior myocardial infarction (MI), ischemic stroke, or symptomatic …

Background It has not been clearly established whether percutaneous coronary intervention
(PCI) can provide an incremental benefit in quality of life over that provided by optimal …