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    • In hypertensive patients, low-dose aspirin proves beneficial, but more-aggressive blood pressure treatment falls short—except in persons with diabetes.

  • Should catheter ablation be the first line of treatment for atrial fibrillation?

    Bruce D. Lindsay, MD
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    • Antiarrhythmic drugs should remain the first line of treatment until trials prove otherwise.

  • Parenteral Fluid Therapy

    R. H. McDonald, M.D
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    Brian F. Mandell, MD, PhD
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    • The ENHANCE trial, evaluating the addition of a second hypocholesterolemic drug (ezetimibe) to a statin using two surrogate end points in a relatively small number of patients, hit the national news when the two surrogates didn’t match up.

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  • The ALLHAT Trial

    Donald G. Vidt, MD
    • Cleveland Clinic Journal of Medicine March 2003, 70 (3) 263-269;
    • Diuretics are unsurpassed in lowering blood pressure, reducing clinical events, tolerability, and low cost.

  • The ACUTE Trial

    Craig R. Asher, MD and Allan L. Klein, MD
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    • A TEE-guided approach showed no advantage over conventional management in rates of embolic events, but shortened the anticoagulation course, allowed for earlier cardioversion, and caused fewer bleeding events.

  • The Mustt Trial

    Stephen Pavia, MD and Bruce L. Wilkoff, MD
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    • Implantable defibrillators, but not antiarrhythmic drugs reduce the mortality rate in MI survivors at high risk.

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    • Patients should be selected for bisphosphonate therapy on the basis of low bone density, not age.

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