Latest Articles
- Goal-directed antihypertensive therapy: Lower may not always be better
At least 16 trials have been done in which patients were randomly assigned different blood pressure goals. Surprisingly, they did not show that a lower target offered significant clinical benefit, and they suggest the potential for harm.
- Hypertension: Don’t worry about the J curve—treat the patient
Concerns over being too aggressive remain theoretical. A far greater problem is that we are still not successfully treating hypertension to even a conservative target.
- MAO inhibitors (December 2010)
A reader comments on the use of monoamine oxidase inhibitors to treat depression (December 2010) and on the treatment of gout in patients with chronic kidney disease (December 2010).
- Airway pressure release ventilation: An alternative mode of mechanical ventilation in acute respiratory distress syndrome
This mode may be useful in situations in which the lungs need to be recruited (reinflated) and held open.
Proton pump inhibitor side effects and drug interactions: Much ado about nothing?In general, the safety of this class of drugs has been excellent. However, epidemiologic studies have indicated risks that are biologically plausible.
- Premenopausal osteoporosis, an overlooked consequence of anorexia nervosa
Particularly at risk are female athletes. The etiology is complex; the key treatment is to restore body weight.
- A 31-year-old man with abdominal pain and a rectal nodule
He has had pain and diarrhea for 4 days. What is the likely cause?
- Do patients with prosthetic joints require dental antimicrobial prophylaxis?
The authors contend that the available evidence does not support routine prophylaxis before dental procedures.
- Series Introduction
To keep our readers up to date on progress in palliative medicine, we are presenting a series of articles on the topic.