CHEST 2023

Highlights from CHEST 2023 Annual Meeting, held from October 8 – 11, 2023.

Treprostinil rapid-induction protocol yields improvements using expanded 4-strata risk stratification model

Presenter: Veronica Franco, MD, Ohio State University, Columbus, OH

Initiating oral treprostinil after a shortened course of parenteral treprostinil led to more patients with pulmonary arterial hypertension achieving a low-risk status at 16 weeks, as measured by the newer 4-strata risk stratification model.

Using a machine-learning model for pulmonary arterial hypertension can help pinpoint key features linked to future clinical worsening

Presenter: Hilary M. DuBrock, MD, associate professor, Division of Pulmonary and Critical Care, Mayo Clinic Rochester, MN

Machine-learning models can help identify clinical characteristics associated with worsening disease in patients with PAH, which potentially could lead to earlier intervention and improved patient outcomes.

Pulmonary hypertension is linked to worse outcomes in hospitalized patients with the acute respiratory distress syndrome

Presenter: Kaushik Kumar, MD, Resident Physician, MedStar Health Internal Medicine, Georgetown University, Baltimore, MD

A recent study showed that patients with the acute respiratory distress syndrome (ARDS) and coexisting pulmonary hypertension had worse in-hospital mortality, length of stay, and cost outcomes than those with ARDS alone.

Prostacyclin analogue benefit consistent in PAH patients with underlying cardiovascular conditions

Presenter: Jean M. Elwing, MD, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

Oral treprostinil reduced the risk of clinical worsening in patients with pulmonary arterial hypertension, with and without cardiovascular comorbidities, according to researchers who conducted a post hoc analysis of a randomized, placebo-controlled trial.

Microbiome changes linked to improved outcomes following dietary intervention in WTC firefighters

Presenter: Rachel Lam, BS, NYU Grossman School of Medicine, Department of Medicine, New York, NY

In firefighters with lung injury from particulate matter exposure at the World Trade Center, a low-calorie Mediterranean-style diet induced bacterial alterations, which may help explain the improved health outcomes seen in the FIREHOUSE clinical trial.

Timely, appropriate fluid resuscitation increases survival rates in patients with pulmonary arterial hypertension hospitalized for sepsis

Presenter: Haidee Chen, BA, David Geffen School of Medicine at UCLA, Los Angeles, CA

In patients with pulmonary arterial hypertension who are hospitalized for sepsis, treatment with appropriate fluid resuscitation within 24 hours significantly increases survival rates.